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17(R)-Resolvin D1

Catalog No. T35946 CAS 528583-91-7

Synonyms: Aspirin-triggered Resolvin D1, 17(R)-Resolvin D1

Resolvins are a family of potent lipid mediators derived from both eicosapentaenoic acid and docosahexaenoic acid.[1] In addition to being anti-inflammatory, resolvins promote the resolution of the inflammatory response back to a non-inflamed state.[2] Resolvin D1 is produced physiologically from the sequential oxygenation of DHA by 15- and 5-lipoxygenase.[1] 17(R)-RvD1 is an aspirin-triggered epimer of RvD1 that reduces human polymorphonuclear leukocyte (PMN) transendothelial migration, the earliest event in acute inflammation, with equipotency to RvD1 (EC50 = ~30 nM).[3] 17(R)-RvD1 exhibits a dose-dependent reduction in leukocyte infiltration in a mouse model of peritonitis with maximal inhibition of ~35% at a 100 ng dose.[3] In contrast to RvD1, the aspirin-triggered form resists rapid inactivation by eicosanoid oxidoreductases. Analytical and biological comparisons of synthetic 17(R)-RvD1 with endogenously derived 17(R)-RvD1 have confirmed its identity as matching the natural product.[4]

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17(R)-Resolvin D1, CAS 528583-91-7

Pack Size	Availability	Price/USD
10 μg	35 days	$ 383.00
25 μg	35 days	$ 863.00
50 μg	35 days	$ 1,620.00
100 μg	35 days	$ 2,480.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Synonyms	Aspirin-triggered Resolvin D1, 17(R)-Resolvin D1
Molecular Weight	376.493
Formula	C22H32O5
CAS No.	528583-91-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

PBS (pH 7.2): 0.05 mg/mL

References and Literature

1. Hong, S., Gronert, K., Devchand, P.R., et al. Novel docosatrienes and 17S-resolvins generated from docosahexaenoic acid in murine brain, human blood, and glial cells. Autacoids in anti-inflammation. J. Biol. Chem. 278(17), 14677-14687 (2003). 2. Ariel, A., and Serhan, C.N. Resolvins and protectins in the termination program of acute inflammation. TRENDS in Immunology 28(4), 176-183 (2007). 3. Sun, Y.P., Oh, S.F., Uddin, J., et al. Resolvin D1 and its aspirin-triggered 17R epimer stereochemical assignments, anti-inflammatory properties, and enzymatic inactivation. The Journal of Biological Chemisty 282(13), 9323-9334 (2007). 4. Serhan, C. . (2007).

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Keywords

17(R)-Resolvin D1 528583-91-7 17(R)-Resolvin D-1 17(R) Resolvin D1 Aspirin-triggered Resolvin D1 17(R)Resolvin D1 17Resolvin D1 inhibitor inhibit

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