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Balovaptan

Name: Balovaptan
Brand: TargetMol
SKU: T14494
Price: 60 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T14494Cas No. 1228088-30-9

Alias RG7314

Balovaptan (RG7314) is a highly potent and selective brain-penetrant vasopressin 1a (hV1a) receptor antagonist, with Kis of 1 and 39 nM for human (hV1a) and mouse (mV1a) receptors. It is used for the research of autism.

Balovaptan

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Purity: 99.88%

Catalog No. T14494Alias RG7314Cas No. 1228088-30-9

Pack Size	Price	Availability
5 mg	$60	In Stock
10 mg	$97	In Stock
25 mg	$197	In Stock
50 mg	$318	In Stock
100 mg	$497	In Stock
1 mL x 10 mM (in DMSO)	$67	In Stock

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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.88%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Balovaptan (RG7314) is a highly potent and selective brain-penetrant vasopressin 1a (hV1a) receptor antagonist, with Kis of 1 and 39 nM for human (hV1a) and mouse (mV1a) receptors. It is used for the research of autism.
Targets&IC50	V1a receptor:39 nM(ki) mouse, V1a receptor:1 nM (ki) human
In vitro	Balovaptan (RG7314) is a highly potent and selective brain-penetrant vasopressin 1a (hV1a) receptor antagonist, with Kis of 1 and 39 nM for hV1a and mhV1a. It is used for the research of autism. Balovaptan shows >30000-fold selectivity for hV1a over hV2 receptors, 9891-fold selectivity over hOTR (human oxytocin receptor)[1].
Synonyms	RG7314

Chemical Properties

Molecular Weight	409.91
Formula	C₂₂H₂₄ClN₅O
Cas No.	1228088-30-9
Smiles	[H][C@@]1(CC[C@@H](CC1)Oc1ccccn1)c1nnc2CN(C)Cc3cc(Cl)ccc3-n12
Relative Density.	1.39 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 62.5 mg/mL (152.47 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.88 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4396 mL	12.1978 mL	24.3956 mL	121.9780 mL
5 mM	0.4879 mL	2.4396 mL	4.8791 mL	24.3956 mL
10 mM	0.2440 mL	1.2198 mL	2.4396 mL	12.1978 mL
20 mM	0.1220 mL	0.6099 mL	1.2198 mL	6.0989 mL
50 mM	0.0488 mL	0.2440 mL	0.4879 mL	2.4396 mL
100 mM	0.0244 mL	0.1220 mL	0.2440 mL	1.2198 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc