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Levocetirizine Dihydrochloride

🥰Excellent
Catalog No. T22354Cas No. 130018-87-0
Alias Xyzal Dihydrochloride, (-)-Cetirizine Dihydrochloride

Levocetirizine Dihydrochloride (Xyzal Dihydrochloride) is a third-generation peripheral H1-receptor antagonist. Acting as an antihistaminic agent, it specifically targets the histamine H1-receptor. Levocetirizine Dihydrochloride is the R-enantiomer of Cetirizine, which gives it a higher affinity for the H1-receptor than the S-enantiomer. Due to this enhanced affinity, Levocetirizine Dihydrochloride is effective in treating allergic rhinitis and chronic idiopathic urticaria.

Levocetirizine Dihydrochloride
Other Forms of Levocetirizine Dihydrochloride:

Levocetirizine Dihydrochloride

🥰Excellent
Purity: 99.89%
Catalog No. T22354Alias Xyzal Dihydrochloride, (-)-Cetirizine DihydrochlorideCas No. 130018-87-0
Levocetirizine Dihydrochloride (Xyzal Dihydrochloride) is a third-generation peripheral H1-receptor antagonist. Acting as an antihistaminic agent, it specifically targets the histamine H1-receptor. Levocetirizine Dihydrochloride is the R-enantiomer of Cetirizine, which gives it a higher affinity for the H1-receptor than the S-enantiomer. Due to this enhanced affinity, Levocetirizine Dihydrochloride is effective in treating allergic rhinitis and chronic idiopathic urticaria.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
25 mg$42In StockIn Stock
50 mg$60In StockIn Stock
100 mg$85In StockIn Stock
500 mg$197-In Stock
1 mL x 10 mM (in DMSO)$29In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.89%
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Product Introduction

Bioactivity
Description
Levocetirizine Dihydrochloride (Xyzal Dihydrochloride) is a third-generation peripheral H1-receptor antagonist. Acting as an antihistaminic agent, it specifically targets the histamine H1-receptor. Levocetirizine Dihydrochloride is the R-enantiomer of Cetirizine, which gives it a higher affinity for the H1-receptor than the S-enantiomer. Due to this enhanced affinity, Levocetirizine Dihydrochloride is effective in treating allergic rhinitis and chronic idiopathic urticaria.
In vivo
Levocetirizine (0.4 mg/kg; oral administration; male Sprague-Dawley rats) yields a Cmax of 0.34 μg/mL, an AUC0-t of 3.26 μg h/mL, an AUC0-∞ of 3.67 μg h/mL, and a t1/2 of 2.34 hours in Sprague-Dawley rats[1].
SynonymsXyzal Dihydrochloride, (-)-Cetirizine Dihydrochloride
Chemical Properties
Molecular Weight461.81
FormulaC21H27Cl3N2O3
Cas No.130018-87-0
SmilesO=C(O)COCCN1CCN([C@@H](C2=CC=C(Cl)C=C2)C3=CC=CC=C3)CC1.Cl.Cl
Relative Density.no data available
ColorWhite
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
H2O: 90 mg/mL (194.9 mM), Sonication is recommended.
DMSO: 50 mg/mL (108.27 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.33 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO/H2O
1mg5mg10mg50mg
1 mM2.1654 mL10.8270 mL21.6539 mL108.2696 mL
5 mM0.4331 mL2.1654 mL4.3308 mL21.6539 mL
10 mM0.2165 mL1.0827 mL2.1654 mL10.8270 mL
20 mM0.1083 mL0.5413 mL1.0827 mL5.4135 mL
50 mM0.0433 mL0.2165 mL0.4331 mL2.1654 mL
100 mM0.0217 mL0.1083 mL0.2165 mL1.0827 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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%
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Keywords

XyzalLevocetirizine DihydrochlorideLevocetirizineHistamineReceptorHistamine ReceptorH1 receptorCetirizine DihydrochlorideCetirizine
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