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SIRT1-IN-3

Catalog No. T60631 CAS 2470969-91-4

SIRT1-IN-3 (compound 3j) is a potent and selective inhibitor of silent information regulator 1 (SIRT1) with an IC 50 of 4.2 μM [1].

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SIRT1-IN-3, CAS 2470969-91-4

Pack Size	Availability	Price/USD
25 mg	6-8 weeks	$ 1,520.00
50 mg	6-8 weeks	$ 1,980.00
100 mg	6-8 weeks	$ 2,500.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

Chemical Properties

Storage & Solubility Information

Description

SIRT1-IN-3 (compound 3j) is a potent and selective inhibitor of silent information regulator 1 (SIRT1) with an IC 50 of 4.2 μM [1].

In vitro

SIRT1-IN-3 (compound 3j), at concentrations ranging from 0 to 100 μM over 48 hours, effectively inhibits the growth of several human cancer cell lines (including K562, HCT-116, H460, HepG2, A549, and MCF-7), demonstrating specific anti-proliferative properties. Moreover, this compound exhibits minimal cytotoxic effects on normal cell lines such as 293T and HUVEC. The cytotoxicity assay outcomes illustrate that the inhibition concentrations (IC50) for cancer cell lines K562, HCT-116, H460, HepG2, A549, and MCF-7 are 47, 41, 66, 93, 52, and 64 μM, respectively, indicating potency in a broad range of tumor types. Conversely, the IC50 values for non-cancerous 293T and HUVEC cells are relatively similar, at 49 and 45 μM, respectively, highlighting the compound's low toxicity toward normal human cells.

Molecular Weight	295.17
Formula	C13H15BrN2O
CAS No.	2470969-91-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Dose Conversion

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
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The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

SIRT1-IN-3 2470969-91-4 inhibitor inhibit

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