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Anti-Phospho-HER2/ErbB2 (Tyr1221, 1222) Antibody (6Q103)

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Catalog No. TMAY-01653
Alias VSCN2, TKR1, Phospho-HER2/ErbB2 (Y1221, 1222), p-HER2/ErbB2 (Y1221, 1222), p-HER2/ErbB2 (Tyr1221, 1222), p185(erbB2), NGL, NEU, MLN-19, MLN19, MLN 19, HER-2/neu, HER2/ErbB2 (p-Y1221, 1222), HER2/ErbB2 (p-Tyr1221, 1222), HER-2, HER2, Erb-B2, ErbB2, c-ERB-2, c-ERB2, CD340

Anti-Phospho-HER2/ErbB2 (Tyr1221, 1222) Antibody (6Q103) is a Rabbit antibody targeting Phospho-HER2/ErbB2 (Tyr1221, 1222). Anti-Phospho-HER2/ErbB2 (Tyr1221, 1222) Antibody (6Q103) can be used in WB.

Anti-Phospho-HER2/ErbB2 (Tyr1221, 1222) Antibody (6Q103)

Anti-Phospho-HER2/ErbB2 (Tyr1221, 1222) Antibody (6Q103)

😃Good
Catalog No. TMAY-01653Alias VSCN2, TKR1, Phospho-HER2/ErbB2 (Y1221, 1222), p-HER2/ErbB2 (Y1221, 1222), p-HER2/ErbB2 (Tyr1221, 1222), p185(erbB2), NGL, NEU, MLN-19, MLN19, MLN 19, HER-2/neu, HER2/ErbB2 (p-Y1221, 1222), HER2/ErbB2 (p-Tyr1221, 1222), HER-2, HER2, Erb-B2, ErbB2, c-ERB-2, c-ERB2, CD340
Anti-Phospho-HER2/ErbB2 (Tyr1221, 1222) Antibody (6Q103) is a Rabbit antibody targeting Phospho-HER2/ErbB2 (Tyr1221, 1222). Anti-Phospho-HER2/ErbB2 (Tyr1221, 1222) Antibody (6Q103) can be used in WB.
Pack SizePriceAvailabilityQuantity
20 μL$80 7-10 days
100 μL$233 7-10 days
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Product Introduction

Bioactivity
Description
Antibody Type: Rabbit Monoclonal

Application: WB

Reactivity: Human
AliasVSCN2, TKR1, Phospho-HER2/ErbB2 (Y1221, 1222), p-HER2/ErbB2 (Y1221, 1222), p-HER2/ErbB2 (Tyr1221, 1222), p185(erbB2), NGL, NEU, MLN-19, MLN19, MLN 19, HER-2/neu, HER2/ErbB2 (p-Y1221, 1222), HER2/ErbB2 (p-Tyr1221, 1222), HER-2, HER2, Erb-B2, ErbB2, c-ERB-2, c-ERB2, CD340
Ig Type
Rabbit IgG
Clone
6Q103
Reactivity
Human
Verified Activity
1. Western blot analysis of extracts from serum-starved SkBr3, untreated (-) or treated with EGF (200 ng/mL, 10 min; +), using Phospho-HER2/ErbB2 (Tyr1221, 1222) rabbit Monoclonal Antibody at 1:200000 dilution (upper) or Anti-Her2/ERBB2 Antibody, Mouse Monoclonal at 1:500 dilution (lower).
2. Western blot analysis of extracts from serum-starved SkBr3, untreated (line A); treated with EGF (200 ng/mL, 10 min), without peptide (line B) or antigen-specific phosphopeptide (line C) or antigen-specific peptide (line D) using Phospho-HER2/ErbB2 (Tyr1221, 1222) rabbit monoclonal Antibody at 1:200000 dilution. (Validation Experiment)
3. Western blot analysis of extracts from serum-starved SkBr3, untreated (line A); treated with EGF (200 ng/mL, 10 min) (line B); treated with EGF and λ-phosphatase (line C) using Phospho-HER2/ErbB2 (Tyr1221, 1222) rabbit monoclonal Antibody at 1:200000 dilution. (Validation Experiment)
4. Western blot analysis of extracts from serum-starved SkBr3, treated with EGF (200 ng/mL, 10 min), using Phospho-HER2/ErbB2 (Tyr1221, 1222) Antibody, Rabbit Mab and other brands’ antibodies (Company C) at dilution of 1:300000, 1:100000 and 1:10000. (Validation Experiment)
Application
WB
Recommended Dose
WB: 1:10000-1:200000
Antibody Type
Monoclonal
Host SpeciesRabbit
ConstructionThis antibody was obtained from a rabbit immunized with a synthetic phosphopeptide corresponding to residues around (Tyr1221, 1222) of human HER2/ErbB2.
PurificationProtein A
AppearanceLiquid
Formulation10 mM sodium HEPES, 150 mM NaCl, 100 μg/mL BSA, 50% glycerol, pH 7.5
Research BackgroundHuman epidermal growth factor receptor 2 (HER2), also known as ErbB2, NEU, and CD340, is a type I membrane glycoprotein and belongs to the epidermal growth factor (EGF) receptor family. HER2 protein cannot bind growth factors due to the lacking of ligand binding domain of its own and autoinhibited constitutively. However, HER2 forms a heterodimer with other ligand-bound EGF receptor family members, therefore stabilizes ligand binding and enhances kinase-mediated activation of downstream molecules. HER2 plays a key role in development, cell proliferation and differentiation. HER2 gene has been reported to associate with malignancy and a poor prognosis in numerous carcinomas, including breast, prostate, ovarian, lung cancers and so on.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy
Related Conjugates and Formulations
Conjucates
Unconjugated
Antigen Details
Immunogen
A synthetic peptide: residues around (Tyr1221, 1222) of human HER2/ErbB2.
Antigen Species
Human
Biology Area
Cancer Drug Targets, Receptor Tyrosine Kinases (RTKs)
Chemical Properties
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
TransportShipping with blue ice.

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