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CU-115

Catalog No. T9645 CAS 2471982-20-2

Synonyms: N-(4-(3,5-bis(trifluoromethyl)phenoxy)phenyl)-2-fluoro-6-iodobenzamide

CU-115 is a selective and potent TLR8 antagonist with IC50 of 1.04 µM and =<50 µM for TLR8 and TLR7, respectively. CU-115 decreases production of TNF-α and IL-1β activated by R-848 in THP-1 cells.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

CU-115, CAS 2471982-20-2

Pack Size	Availability	Price/USD
1 mg	In stock	$ 89.00
2 mg	In stock	$ 148.00
5 mg	In stock	$ 297.00
10 mg	In stock	$ 478.00
25 mg	In stock	$ 872.00
50 mg	In stock	$ 1,220.00
100 mg	In stock	$ 1,650.00
1 mL * 10 mM (in DMSO)	In stock	$ 373.00

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Purity: 100%

Biological Description

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Description

CU-115 is a selective and potent TLR8 antagonist with IC50 of 1.04 µM and =>50 µM for TLR8 and TLR7, respectively. CU-115 decreases production of TNF-α and IL-1β activated by R-848 in THP-1 cells.

In vitro

CU-115 (1, 5, and 20 µM) inhibits TLR9 to 10-25% inhibition. CU-115 (5-20 µM) inhibits increases in the activity of type I IFN transcriptional induced by the ssRNA nucleic acid ligands 3p-hpRNA or G3-YSD. CU-115 (5-20 µM) abolishes the TNF-α production activated by R848 (1 µg/ml) and represses the expression of IL-1β in hTHP-1 cells. CU-115 does not modulate the NF-kB inhibition induced by Pam2CSK4, Pam3CSK4, LPS, R848, Poly(I:C), and Flic in HEK-293 TLR1/2, TLR2/6, TLR3, and TLR4 cells[1].

Synonyms	N-(4-(3,5-bis(trifluoromethyl)phenoxy)phenyl)-2-fluoro-6-iodobenzamide
Molecular Weight	569.21
Formula	C21H11F7INO2
CAS No.	2471982-20-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 90 mg/mL (158.1 mM), Sonication is recommended.

References and Literature

1. Rosaura Padilla-Salinas, et al. Discovery of Novel Small Molecule Dual Inhibitors Targeting Toll-Like Receptors 7 and 8. J Med Chem. 2019 Nov 27;62(22):10221-10244.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Membrane Protein-targeted Compound Library Bioactive Compound Library Immunology/Inflammation Compound Library Bioactive Compounds Library Max

Related Products

Related compounds with same targets

Semapimod tetrahydrochloride Polygalasaponin F TLR7/8 agonist 1 dihydrochloride SM360320 Selgantolimod Atractylenolide I C29 MD2-TLR4-IN-1

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

CU-115 2471982-20-2 Immunology/Inflammation TLR CU115 CU 115 N-(4-(3,5-bis(trifluoromethyl)phenoxy)phenyl)-2-fluoro-6-iodobenzamide inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.