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(Z)-Capsaicin

Name: (Z)-Capsaicin
Brand: TargetMol
SKU: T1109
Price: 48 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1109Cas No. 25775-90-0

Alias Zucapsaicin, Civamide, cis-Capsaicin

(Z)-Capsaicin (Zucapsaicin) is a medication used to treat osteoarthritis of the knee and Others neuropathic pain.(Z)-Capsaicin is a synthetic cis isomer of natural capsaicin that has shown therapeutic efficacy in pain accompanying osteoarthritis of the knee.

(Z)-Capsaicin

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Purity: 98.91%

Catalog No. T1109Alias Zucapsaicin, Civamide, cis-CapsaicinCas No. 25775-90-0

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
10 mg	$48	In Stock	In Stock
50 mg	$158	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98.91%

Appearance:Solid

Color:White to Yellow

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Product Introduction

(Z)-Capsaicin AI Summary

(Z)-Capsaicin demonstrates significant bioactivity across various assays and targets. In vivo, subcutaneous administration at 40 mg/kg in a mouse hot plate test resulted in a latency time greater than 39.9, with 6 out of 7 animals responding. However, it showed 0.0% analgesia in a rat hot plate test after oral administration at 300 mg/kg. Topically, it inhibited Croton oil-induced inflammation in a mouse ear test by 79.5%. The compound also exhibited acute toxicity with a 50% lethality rate at 50 mg/kg intraperitoneally in mice. In vitro, (Z)-Capsaicin exhibits broad-spectrum inhibitory activities, including against human Jumonji Domain Containing 2E (JMJD2E), Cruzain, Cytochrome P450 enzymes (2C19, 2D6, 2C9, 3A4), and Aldehyde Dehydrogenase 1 (ALDH1A1). It also inhibits Anthrax Lethal Toxin Internalization and Caspase-1. Additionally, it acts as an activator of Cytochrome P450 3A4 and exhibits modulation of TRPV1 receptors with a Ki value of 1080 nM and agonist activity with an EC50 value of 28.2 nM, increasing 45Ca2+ uptake. (Z)-Capsaicin shows inhibitory activity against the SARS-CoV-2 3CL-Pro protease, with 12.44% inhibition at 20 μM detected via FRET assay. In cellular assays, it demonstrated minimal antiviral activity against SARS-CoV-2-induced cytotoxicity in VERO-6 cells at 10 μM concentration. The compound also displays antifungal effects against Candida albicans and antibacterial activity against multiple bacterial strains, including Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Acinetobacter baumannii, and Staphylococcus aureus MRSA, suggesting potential as a broad-spectrum antimicrobial agent..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	(Z)-Capsaicin (Zucapsaicin) is a medication used to treat osteoarthritis of the knee and Others neuropathic pain.(Z)-Capsaicin is a synthetic cis isomer of natural capsaicin that has shown therapeutic efficacy in pain accompanying osteoarthritis of the knee.
Synonyms	Zucapsaicin, Civamide, cis-Capsaicin

Chemical Properties

Molecular Weight	305.41
Formula	C₁₈H₂₇NO₃
Cas No.	25775-90-0
Smiles	COC1=C(O)C=CC(CNC(=O)CCCC\C=C/C(C)C)=C1
Relative Density.	1.041g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 163.3 mg/mL (534.69 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.55 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2743 mL	16.3714 mL	32.7429 mL	163.7144 mL
5 mM	0.6549 mL	3.2743 mL	6.5486 mL	32.7429 mL
10 mM	0.3274 mL	1.6371 mL	3.2743 mL	16.3714 mL
20 mM	0.1637 mL	0.8186 mL	1.6371 mL	8.1857 mL
50 mM	0.0655 mL	0.3274 mL	0.6549 mL	3.2743 mL
100 mM	0.0327 mL	0.1637 mL	0.3274 mL	1.6371 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc