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Trilostane

🥰Excellent
Catalog No. T1473Cas No. 13647-35-3
Alias Win 24540

Trilostane (Win 24540) is a synthetic androstane derivative with adrenocortical suppressive properties, reversibly inhibiting 3 beta-hydroxysteroid dehydrogenase delta [5-4] isomerase in the adrenal cortex.

Trilostane
Other Forms of Trilostane:
Trilostane-d3TMIH-0587
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Trilostane

🥰Excellent
Purity: 99.46%
Catalog No. T1473Alias Win 24540Cas No. 13647-35-3
Trilostane (Win 24540) is a synthetic androstane derivative with adrenocortical suppressive properties, reversibly inhibiting 3 beta-hydroxysteroid dehydrogenase delta [5-4] isomerase in the adrenal cortex.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
10 mg$39In StockIn Stock
25 mg$55In StockIn Stock
50 mg$72In StockIn Stock
100 mg$89In StockIn Stock
200 mg$113In StockIn Stock
500 mg$188In StockIn Stock
1 mL x 10 mM (in DMSO)$43In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information

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Purity:99.46%
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COA HNMR LCMS

Product Introduction

Bioactivity
Description
Trilostane (Win 24540) is a synthetic androstane derivative with adrenocortical suppressive properties, reversibly inhibiting 3 beta-hydroxysteroid dehydrogenase delta [5-4] isomerase in the adrenal cortex.
In vitro
In MCF-7, Trilostane affects the transcription of genes involved in cell cycle regulation, cell adhesion and matrix formation.
In vivo
In MCF-7, Trilostane affects the transcription of genes involved in cell cycle regulation, cell adhesion and matrix formation.
SynonymsWin 24540
Chemical Properties
Molecular Weight329.43
FormulaC20H27NO3
Cas No.13647-35-3
SmilesC[C@@]12[C@]3([C@](O3)(C(O)=C(C#N)C1)[H])CC[C@@]4([C@@]2(CC[C@@]5(C)[C@]4(CC[C@@H]5O)[H])[H])[H]
Relative Density.1.25g/cm3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 45 mg/mL (136.6 mM), Sonication is recommended.
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
H2O: < 1 mg/mL (insoluble or slightly soluble)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.0355 mL15.1777 mL30.3555 mL151.7773 mL
5 mM0.6071 mL3.0355 mL6.0711 mL30.3555 mL
10 mM0.3036 mL1.5178 mL3.0355 mL15.1777 mL
20 mM0.1518 mL0.7589 mL1.5178 mL7.5889 mL
50 mM0.0607 mL0.3036 mL0.6071 mL3.0355 mL
100 mM0.0304 mL0.1518 mL0.3036 mL1.5178 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
% DMSO
%
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Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Win-24540Win24540TrilostaneInhibitorinhibit3 β-hydroxysteroid dehydrogenase
Related Tags: buy Trilostane | purchase Trilostane | Trilostane cost | order Trilostane | Trilostane chemical structure | Trilostane in vivo | Trilostane in vitro | Trilostane formula | Trilostane molecular weight
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