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Trilostane

Name: Trilostane
Brand: TargetMol
SKU: T1473
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1473Cas No. 13647-35-3

Alias Win 24540

Trilostane (Win 24540) is a synthetic androstane derivative with adrenocortical suppressive properties, reversibly inhibiting 3 beta-hydroxysteroid dehydrogenase delta [5-4] isomerase in the adrenal cortex.

Trilostane

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Purity: 99.46%

Catalog No. T1473Alias Win 24540Cas No. 13647-35-3

Pack Size	Price	Availability
10 mg	$39	In Stock
25 mg	$55	In Stock
50 mg	$72	In Stock
100 mg	$89	In Stock
200 mg	$113	In Stock
500 mg	$188	In Stock
1 mL x 10 mM (in DMSO)	$43	In Stock

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Batch Information

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Purity:99.46%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	Trilostane (Win 24540) is a synthetic androstane derivative with adrenocortical suppressive properties, reversibly inhibiting 3 beta-hydroxysteroid dehydrogenase delta [5-4] isomerase in the adrenal cortex.
In vitro	In MCF-7, Trilostane affects the transcription of genes involved in cell cycle regulation, cell adhesion and matrix formation.
In vivo	In MCF-7, Trilostane affects the transcription of genes involved in cell cycle regulation, cell adhesion and matrix formation.
Synonyms	Win 24540

Chemical Properties

Molecular Weight	329.43
Formula	C₂₀H₂₇NO₃
Cas No.	13647-35-3
Smiles	C[C@@]12[C@]3([C@](O3)(C(O)=C(C#N)C1)[H])CC[C@@]4([C@@]2(CC[C@@]5(C)[C@]4(CC[C@@H]5O)[H])[H])[H]
Relative Density.	1.25g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (136.6 mM), Sonication is recommended.

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

H2O: < 1 mg/mL (insoluble or slightly soluble)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0355 mL	15.1777 mL	30.3555 mL	151.7773 mL
5 mM	0.6071 mL	3.0355 mL	6.0711 mL	30.3555 mL
10 mM	0.3036 mL	1.5178 mL	3.0355 mL	15.1777 mL
20 mM	0.1518 mL	0.7589 mL	1.5178 mL	7.5889 mL
50 mM	0.0607 mL	0.3036 mL	0.6071 mL	3.0355 mL
100 mM	0.0304 mL	0.1518 mL	0.3036 mL	1.5178 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc