Shopping Cart

Your shopping cart is currently empty

Trilostane

Name: Trilostane
Brand: TargetMol
SKU: T1473
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

🥰Excellent

Catalog No. T1473Cas No. 13647-35-3

Alias Win 24540

Trilostane (Win 24540) is a synthetic androstane derivative with adrenocortical suppressive properties, reversibly inhibiting 3 beta-hydroxysteroid dehydrogenase delta [5-4] isomerase in the adrenal cortex.

Trilostane

Copy Product Info

🥰Excellent

Purity: 99.46%

Catalog No. T1473Alias Win 24540Cas No. 13647-35-3

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$39	In Stock	In Stock
25 mg	$55	In Stock	In Stock
50 mg	$72	In Stock	In Stock
100 mg	$89	In Stock	In Stock
200 mg	$113	In Stock	In Stock
500 mg	$188	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$43	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.46%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Trilostane AI Summary

Trilostane exhibits a range of bioactivities and pharmacological profiles. Primarily, it functions as an inhibitor of human tyrosyl-DNA phosphodiesterase 1 (TDP1), with a confirmed potency of 33,498.3 nM. It also demonstrates inhibition of various human transport proteins, such as BSEP, MRP2, MRP3, and MRP4, with IC50 values exceeding 133,000.0 nM. Additionally, the compound shows antiviral properties against SARS-CoV-2, both in HRCE cells and VERO-6 cells. Specifically, it exhibits inhibition of SARS-CoV-2 induced cytotoxicity in Caco-2 cells (2.7% at 10 µM) and in VERO-6 cells (IC50 > 20,000.0 nM). It also inhibits the SARS-CoV-2 3CL-Pro protease by 4.581% at a 20 µM concentration. Furthermore, compound 674858 shows a modest effect on human HDAC6, with inhibition rates of -0.07% and 1.06% for commercial and custom peptide substrates, respectively. Finally, it binds to several human and rat receptors and proteins with AC50 values over 10,000.0 nM and has demonstrated agonist and antagonist activities towards various receptors with similarly high AC50 values..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Trilostane (Win 24540) is a synthetic androstane derivative with adrenocortical suppressive properties, reversibly inhibiting 3 beta-hydroxysteroid dehydrogenase delta [5-4] isomerase in the adrenal cortex.
In vitro	In MCF-7, Trilostane affects the transcription of genes involved in cell cycle regulation, cell adhesion and matrix formation.
In vivo	In MCF-7, Trilostane affects the transcription of genes involved in cell cycle regulation, cell adhesion and matrix formation.
Synonyms	Win 24540

Chemical Properties

Molecular Weight	329.43
Formula	C₂₀H₂₇NO₃
Cas No.	13647-35-3
Smiles	C[C@@]12[C@]3([C@](O3)(C(O)=C(C#N)C1)[H])CC[C@@]4([C@@]2(CC[C@@]5(C)[C@]4(CC[C@@H]5O)[H])[H])[H]
Relative Density.	1.25g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (136.6 mM), Sonication is recommended.

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

H2O: < 1 mg/mL (insoluble or slightly soluble)

In Vivo Formulation

10% DMSO+90% Corn Oil: 2 mg/mL (6.07 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0355 mL	15.1777 mL	30.3555 mL	151.7773 mL
5 mM	0.6071 mL	3.0355 mL	6.0711 mL	30.3555 mL
10 mM	0.3036 mL	1.5178 mL	3.0355 mL	15.1777 mL
20 mM	0.1518 mL	0.7589 mL	1.5178 mL	7.5889 mL
50 mM	0.0607 mL	0.3036 mL	0.6071 mL	3.0355 mL
100 mM	0.0304 mL	0.1518 mL	0.3036 mL	1.5178 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc