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RLY-2608

Name: RLY-2608
Brand: TargetMol
SKU: T81264
Price: 538 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T81264Cas No. 2733573-94-7

Alias Zovegalisib, RLY2608, RLY 2608

RLY-2608 is a selective mutant PI3Kα inhibitor that inhibits tumor growth in a PIK3CA mutant xenograft model.

RLY-2608

🥰Excellent

Purity: 98.7%

Catalog No. T81264Alias Zovegalisib, RLY2608, RLY 2608Cas No. 2733573-94-7

RLY-2608 is a selective mutant PI3Kα inhibitor that inhibits tumor growth in a PIK3CA mutant xenograft model.

Pack Size	Price	Availability
1 mg	$538	In Stock
5 mg	$1,070	In Stock
10 mg	$1,730	In Stock
25 mg	$2,580	In Stock
50 mg	$3,480	In Stock
1 mL x 10 mM (in DMSO)	$1,430	In Stock

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This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:98.7%

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	RLY-2608 is a selective mutant PI3Kα inhibitor that inhibits tumor growth in a PIK3CA mutant xenograft model.
Targets&IC50	PI3Kα:4 nM
Synonyms	Zovegalisib, RLY2608, RLY 2608

Chemical Properties

Molecular Weight	608.91
Formula	C₂₉H₁₄ClF₅N₆O₂
Cas No.	2733573-94-7
Smiles	N(C(=O)C1=CC(C(F)(F)F)=CC(F)=C1)C2=C3[C@@H](NC(=O)C3=CC(=C2)C4=C(C#N)N5C(C=C4)=NC=N5)C6=C(Cl)C=CC(F)=C6

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (131.38 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6423 mL	8.2114 mL	16.4228 mL	82.1139 mL
5 mM	0.3285 mL	1.6423 mL	3.2846 mL	16.4228 mL
10 mM	0.1642 mL	0.8211 mL	1.6423 mL	8.2114 mL
20 mM	0.0821 mL	0.4106 mL	0.8211 mL	4.1057 mL
50 mM	0.0328 mL	0.1642 mL	0.3285 mL	1.6423 mL
100 mM	0.0164 mL	0.0821 mL	0.1642 mL	0.8211 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc