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Digeranyl bisphosphonate

Name: Digeranyl bisphosphonate
Brand: TargetMol
SKU: T12452
Price: 263 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T12452Cas No. 878143-03-4

Alias DGBP

Digeranyl bisphosphonate (DGBP) is a potent geranylgeranyl pyrophosphate (GGPP) synthase inhibitor that impedes the geranyl pyrophosphorylation of Rac1 and induces autophagy without causing apoptosis.

Digeranyl bisphosphonate

🥰Excellent

Purity: 98.5%

Catalog No. T12452Alias DGBPCas No. 878143-03-4

Pack Size	Price	Availability
1 mg	$263	In Stock
5 mg	$529	In Stock
10 mg	$848	In Stock
25 mg	$1,520	In Stock
50 mg	$1,980	In Stock
100 mg	$2,500	In Stock

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Bulk & Custom

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:98.5%

Resource Download

COA HNMR HPLC IC PNMR

Product Introduction

Bioactivity

Description	Digeranyl bisphosphonate (DGBP) is a potent geranylgeranyl pyrophosphate (GGPP) synthase inhibitor that impedes the geranyl pyrophosphorylation of Rac1 and induces autophagy without causing apoptosis.
Synonyms	DGBP

Chemical Properties

Molecular Weight	536.4
Formula	C₂₁H₃₄Na₄O₆P₂
Cas No.	878143-03-4
Smiles	C/C(C)=C\CC/C(C)=C/CC(P([O-])([O-])=O)(P([O-])([O-])=O)C/C=C(C)/CC/C=C(C)\C.[Na+].[Na+].[Na+].[Na+]
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: < 0.5 mg/mL (Insoluble)

Ethanol: < 0.5 mg/mL (Insoluble)

H2O: 1.67 mg/mL (3.11 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	1.8643 mL	9.3214 mL	18.6428 mL	93.2140 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc