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TargetMol | Compound Library

PI3K-AKT-mTOR Compound Library

Catalog No. L1300

The PI3K/AKT/mTOR pathway is an intracellular signaling pathway important in regulating the cell cycle. Therefore, it is directly related to cellular quiescence, proliferation, cancer, and longevity. Phosphatidylinositol 3-kinase (PI3K), AKT, a serine/threonine protein kinase also known as protein kinase B (PKB), and mammalian target of rapamycin (mTOR) are 3 major nodes in the pathway. PI3K activation phosphorylates and activates AKT, localizing it in the plasma membrane. AKT can have a number of downstream effects such as activating CREB, inhibiting p27, localizing FOXO in the cytoplasm, activating PtdIns-3ps, and activating mTOR which can affect transcription of p70 or 4EBP1. mTOR is a component of the PI3K/AKT cell survival pathway that monitors the availability of nutrients, mitogenic signals and cellular energy and oxygen levels, a major regulator of the autophagic process, and alterations in components of the mTOR pathway have a major role in tumor progression. Therefore, mTOR is an appealing therapeutic target in many tumors. Encouraging data from preclinical studies have offered new opportunities to fully exploit the therapeutic potential of mTOR targeting in cancer. The PI3K/Akt/mTOR Compound Library by TargetMol, containing 610 compounds targeting PI3K/Akt/mTOR signaling, can be used for high throughput screening and high content screening for new drugs.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

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Catalog No. L1300

PI3K-AKT-mTOR Compound Library

sizeIn stock

  • 1 mg
  • 30 μL x 10 mM (in DMSO)
  • 50 μL x 10 mM (in DMSO)
  • 100 μL x 10 mM (in DMSO)
  • 250 μL x 10 mM (in DMSO)
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Product Description Product Description

  • A unique collection of 610 compounds targeting PI3K/Akt/mTOR signaling for research in PI3K/Akt/mTOR signaling, and drug discovery in diseases involved with PI3K/Akt/mTOR signaling;
  • Effective tool for studying cell growth, proliferation, and apoptosis;
  • Targets include AKT, AMPK, mTOR, PI3K, ATR/ATM, etc;
  • Detailed compound information with structure, target, activity, IC50 value, and biological activity description;
  • Structurally diverse, medicinally active, and cell permeable;
  • NMR and HPLC validated to ensure high purity and quality;

Packaging And Storage Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice
  • This compound library is provided at a concentration of 10 mM in DMSO. A small number of compounds may be provided in different solvents or concentrations due to solubility or stability requirements. Please refer to the specific product information for details.

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PI3K
Apoptosis
mTOR
Akt
Autophagy
AMPK
GSK-3
CDK
DNA-PK
S6 Kinase
ATM/ATR
PDK
Endogenous Metabolite
ERK
NF-κB
Antibacterial
PI4K
PKA
PKC
Wnt/beta-catenin
Parasite
p38 MAPK
Mitophagy
Src
Casein Kinase
Caspase
Dehydrogenase
STAT
VEGFR
PTEN
JNK
SIK
Reactive Oxygen Species
COX
PPAR
Chk
TNF
ROCK
Cytochromes P450
MEK
FLT
MAPK
Phosphatase
HIV Protease
Bcl-2 Family
MELK
Calcium Channel
DYRK
Antibiotic
IL Receptor
Aurora Kinase
Nrf2
IGF-1R
HDAC
DNA/RNA Synthesis
Beta Amyloid
SGK
MMP
Potassium Channel
Influenza Virus
PDE
Prostaglandin Receptor
FKBP
Cannabinoid Receptor
Glucosidase
JAK
Interleukin
IκB/IKK
AChR
PARP
Lipoxygenase
HSV
Raf
Mitochondrial Metabolism
Bcr-Abl
Antifection
FGFR
Microtubule Associated
FAK
HCV Protease
Serine/threonin kinase
FXR
LDL
P-gp
p53
Integrin
Myosin
Epigenetic Reader Domain
TGF-beta/Smad
Beta-Secretase
c-RET
Adenosine Receptor
Rho
EGFR
HIF
ATPase
Carbonic Anhydrase
Antioxidant
Virus Protease
PDGFR
Cholinesterase (ChE)
ATP Citrate Lyase
Sirtuin
BACE
Pim
TRP/TRPV Channel
Adrenergic Receptor
transporter
c-Kit
Gamma-secretase
PLK
HIF/HIF Prolyl-Hydroxylase
Chloride channel
NOS
RAR/RXR
Aryl Hydrocarbon Receptor
Prolyl Endopeptidase (PREP)
Topoisomerase
Opioid Receptor
TLR
LRRK2
Pyroptosis
Tyrosinase
NO Synthase
NPC1L1
RAAS
Tie-2
Estrogen Receptor/ERR
Cholecystokinin Receptor
Acyltransferase
SARS-CoV
Decarboxylase
Y Box Binding Protein 1
Ferroptosis
c-Met/HGFR
gp120/CD4
GTPase
c-Myc
cAMP
ALK
Reverse Transcriptase
GABA Receptor
NOD
ROS Kinase
PERK
HBV
Tyrosine Kinases
E1/E2/E3 Enzyme
Monoamine Transporter
GluR
CRISPR/Cas9
YAP
NADPH
RANKL/RANK
Na-K-Cl cotransporter
CaMK
Antiviral
NOD-like Receptor (NLR)
Monoamine Oxidase
Antifungal
Serine Protease
Glucokinase
Angiotensin-converting Enzyme (ACE)
Trk receptor
c-Fms
Syk
S1P Receptor
Dopamine Receptor
Estrogen/progestogen Receptor
MRP
PYK2
RIP kinase
Fatty Acid Synthase
BCRP
DAPK
Kinesin
ADC Cytotoxin

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