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TargetMol | Compound Library

PI3K-AKT-mTOR Compound Library

Catalog No. L1300

The PI3K/AKT/mTOR pathway is an intracellular signaling pathway important in regulating the cell cycle. Therefore, it is directly related to cellular quiescence, proliferation, cancer, and longevity. Phosphatidylinositol 3-kinase (PI3K), AKT, a serine/threonine protein kinase also known as protein kinase B (PKB), and mammalian target of rapamycin (mTOR) are 3 major nodes in the pathway. PI3K activation phosphorylates and activates AKT, localizing it in the plasma membrane. AKT can have a number of downstream effects such as activating CREB, inhibiting p27, localizing FOXO in the cytoplasm, activating PtdIns-3ps, and activating mTOR which can affect transcription of p70 or 4EBP1. mTOR is a component of the PI3K/AKT cell survival pathway that monitors the availability of nutrients, mitogenic signals and cellular energy and oxygen levels, a major regulator of the autophagic process, and alterations in components of the mTOR pathway have a major role in tumor progression. Therefore, mTOR is an appealing therapeutic target in many tumors. Encouraging data from preclinical studies have offered new opportunities to fully exploit the therapeutic potential of mTOR targeting in cancer. The PI3K/Akt/mTOR Compound Library by TargetMol, containing 420 compounds targeting PI3K/Akt/mTOR signaling, can be used for high throughput screening and high content screening for new drugs.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

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Catalog No. L1300

PI3K-AKT-mTOR Compound Library
sizeIn stock
  • 1 mg
  • 30 μL x 10 mM (in DMSO)
  • 50 μL x 10 mM (in DMSO)
  • 100 μL x 10 mM (in DMSO)
  • 250 μL x 10 mM (in DMSO)
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Product Description Product Description

  • A unique collection of 420 compounds targeting PI3K/Akt/mTOR signaling for research in PI3K/Akt/mTOR signaling, and drug discovery in diseases involved with PI3K/Akt/mTOR signaling;
  • Effective tool for studying cell growth, proliferation, and apoptosis;
  • Targets include AKT, AMPK, mTOR, PI3K, ATR/ATM, etc;
  • Detailed compound information with structure, target, activity, IC50 value, and biological activity description;
  • Structurally diverse, medicinally active, and cell permeable;
  • NMR and HPLC validated to ensure high purity and quality;

Packaging And Storage | TargetMol Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice

Library Customization | TargetMol Library Customization

Compound Library | TargetMol
Targetmol Compound Libraries
can be highly customized!
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Library Customization | TargetMol Library Composition

PI3K
Apoptosis
Autophagy
Akt
mTOR
AMPK
GSK-3
DNA-PK
S6 Kinase
CDK
ATM/ATR
Endogenous Metabolite
PDK
ERK
Antibacterial
NF-κB
PKA
PKC
PI4K
Mitophagy
Parasite
Reactive Oxygen Species
Src
JNK
VEGFR
Caspase
p38 MAPK
Dehydrogenase
ROCK
Chk
Casein Kinase
HIV Protease
PPAR
SIK
PTEN
COX
MAPK
MEK
FLT
Antibiotic
Phosphatase
MELK
Influenza Virus
STAT
Potassium Channel
Calcium Channel
Raf
PDGFR
HSV
IL Receptor
Lipoxygenase
Interleukin
DNA/RNA Synthesis
HDAC
P450
TNF
Carbonic Anhydrase
HCV Protease
Integrin
Adenosine Receptor
Virus Protease
Wnt/beta-catenin
PARP
Adrenergic Receptor
PDE
Glucosidase
JAK
MMP
Aurora Kinase
TGF-beta/Smad
P-gp
transporter
IκB/IKK
Beta Amyloid
HIF
PLK
c-RET
FGFR
SGK
Cannabinoid Receptor
Chloride channel
ATPase
NOS
NPC1L1
Estrogen/progestogen Receptor
YAP
Ferroptosis
Antifungal
Antioxidant
BACE
DYRK
NADPH
RAAS
PERK
MRP
HBV
Estrogen Receptor/ERR
Tyrosine Kinases
Rho
Hck
Serine Protease
Serine/threonin kinase
FXR
Topoisomerase
Myosin
E1/E2/E3 Enzyme
Bcr-Abl
Gamma-secretase
LDL
Mitochondrial Metabolism
BCL
Fatty Acid Synthase
GluR
Epigenetic Reader Domain
IGF-1R
CaMK
EGFR
ATP Citrate Lyase
BCRP
Beta-Secretase
AChE
Antiviral
Prostaglandin Receptor
TLR
LRRK2
Trk receptor
Sirtuin
Nrf2
ALK
c-Fms
CRISPR/Cas9
GABA Receptor
AChR
c-Kit
Tyrosinase
HIF/HIF Prolyl-Hydroxylase
FAK
Kinesin
S1P Receptor

Keywords