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Linvencorvir

Catalog No. T64221 CAS 1808248-05-6

Synonyms: RG7907

Linvencorvir is a hepatitis B virus (HBV) core protein variant modifier used to treat chronic HBV infection.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Linvencorvir, CAS 1808248-05-6

Pack Size	Availability	Price/USD
1 mg	In stock	$ 121.00
5 mg	In stock	$ 313.00
10 mg	In stock	$ 513.00
25 mg	In stock	$ 837.00
50 mg	In stock	$ 1,160.00
100 mg	In stock	$ 1,560.00
1 mL * 10 mM (in DMSO)	In stock	$ 397.00

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Purity: 99.78%

ee: 95.99%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Linvencorvir is a hepatitis B virus (HBV) core protein variant modifier used to treat chronic HBV infection.

In vivo

Linvencorvir (RO7049389) (600/1000 mg; oral; Caucasian and Asian, male and female) followed by 100 μg intravenous [13 C]RO7049389. The model performance in predicting the pharmacokinetic profiles of RO7049389 aligned with clinical observations in Caucasians and was also successfully applied to Asians. Accordingly, the drug disposition pathways for RO7049389 were postulated with newly characterized estimates of the fractions: biliary excretion by P-glycoprotein (~41%), direct glucuronidation via uridine 5'-diphosphoglucuronosyltransferase 1A3 (~11%), hexose conjugation (~6%), oxidation by CYP3A4 (~28%) and other oxidation reactions (~9%). These results support the ongoing clinical development program for RO7049389 and highlight the broader value of PBPK and MB analyses in drug development.[3]

Synonyms	RG7907
Molecular Weight	598.69
Formula	C29H35FN6O5S
CAS No.	1808248-05-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 56.2 mg/mL (94.0 mM), Sonication and heating to 60℃ are recommended.

References and Literature

1. WHO. International Nonproprietary Names for Pharmaceutical Substances (INN). WHO Drug Information. 2021;35(4):1017 2. Zhang W, et al. Discovery of Linvencorvir (RG7907), a Hepatitis B Virus Core Protein Allosteric Modulator, for the Treatment of Chronic HBV Infection. J Med Chem. 2023;66(6):4253-4270. 3. Zhang Y, et al. Evaluation of the drug disposition of RO7049389 with in vitro data and human mass balance supported by physiologically based pharmacokinetic modelling [published online ahead of print, 2023 Jun 1]. Br J Clin Pharmacol.

Related compound libraries

This product is contained In the following compound libraries：

Bioactive Compound Library Bioactive Compounds Library Max

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Linvencorvir 1808248-05-6 Microbiology/Virology Antibiotic HBV RG7907 RG-7907 RG 7907 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.