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Linvencorvir

Name: Linvencorvir
Brand: TargetMol
SKU: T64221
Price: 98 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: RG7907) Copy Product Info

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Synonyms: RG7907

Catalog No. T64221 Copy Product Info

Purity: 99.9%

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Linvencorvir (RG7907) belongs to HBV core protein allosteric modulators (CpAM) and is an orally active HBV core protein inhibitor with potent anti-HBV activity, low CYP3A4 induction, and good metabolic stability. This compound is used for the treatment of chronic hepatitis B virus infection.

Cas No. 1808248-05-6

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Pack Size	Price	USA Stock	Global Stock
1 mg	$98	In Stock	In Stock
5 mg	$263	In Stock	In Stock
10 mg	$378	In Stock	In Stock
25 mg	$612	In Stock	In Stock
50 mg	$818	-	In Stock
100 mg	$1,090	-	In Stock
200 mg	$1,480	-	In Stock
1 mL x 10 mM (in DMSO)	$347	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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Custom-made molecule. TargetMol’s expert synthesis team delivers cost-effective solutions. Contact us for inquiries. Committed to serving you.

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.9%

ee:95.99%

Appearance:Solid

Color:Yellow

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COA CSFC LCMS FNMR HNMR

Product Introduction

Bioactivity

Description	Linvencorvir (RG7907) belongs to HBV core protein allosteric modulators (CpAM) and is an orally active HBV core protein inhibitor with potent anti-HBV activity, low CYP3A4 induction, and good metabolic stability. This compound is used for the treatment of chronic hepatitis B virus infection.
Targets & IC50	HepG2.2.15 cells:6 nM (EC50)
In vitro	Methods: In HepG2.2.15 cells, treatment with different concentrations of Linvencorvir was performed to detect HBV DNA replication levels. Results: Linvencorvir inhibited HBV DNA replication with an EC50 of 62 nM. [1] Methods: In HepG2.117 cells, treatment with different concentrations of Linvencorvir was performed to detect HBV DNA production levels. Results: Linvencorvir inhibited HBV DNA production with an EC50 of 64 nM. [2]
In vivo	Methods: In the AAV-HBV mouse model, oral administration of Linvencorvir (20 mg/kg, once daily) was given for 70 consecutive days, and serum and liver virological indicators as well as liver injury markers were detected. Results: Linvencorvir significantly reduced serum HBsAg, HBeAg, and liver AAV-HBV episome levels, induced hepatocyte apoptosis and proliferation, accompanied by transient ALT elevation.[2] Methods: In the AAV-HBV mouse model, oral administration of Linvencorvir (6-20 mg/kg, once daily) was given for 8 consecutive weeks, and serum HBV DNA, HBsAg, and HBeAg levels were detected. Results: Linvencorvir dose-dependently reduced serum HBV DNA, HBsAg, and HBeAg levels.[3]
Synonyms	RG7907

Chemical Properties

Molecular Weight	598.69
Formula	C₂₉H₃₅FN₆O₅S
Cas No.	1808248-05-6
Smiles	C(OCC)(=O)C=1[C@@H](NC(=NC1CN2C[C@@]3(N(CC2)C(=O)N(CC(C(O)=O)(C)C)C3)[H])C4=NC=CS4)C5=C(C)C(F)=CC=C5

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 128.8 mg/mL (215.14 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6703 mL	8.3516 mL	16.7031 mL	83.5157 mL
5 mM	0.3341 mL	1.6703 mL	3.3406 mL	16.7031 mL
10 mM	0.1670 mL	0.8352 mL	1.6703 mL	8.3516 mL
20 mM	0.0835 mL	0.4176 mL	0.8352 mL	4.1758 mL
50 mM	0.0334 mL	0.1670 mL	0.3341 mL	1.6703 mL
100 mM	0.0167 mL	0.0835 mL	0.1670 mL	0.8352 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc