Shopping Cart
Remove All
Your shopping cart is currently empty
Dostarlimab
(Synonyms: TSR-042, TSR042, GSK-4057190A, GSK4057190A, ANB011, ANB 011) Copy Product Info
🥰Excellent
Synonyms: TSR-042, TSR042, GSK-4057190A, GSK4057190A, ANB011, ANB 011
Catalog No. T76850 Copy Product Info
🥰Excellent
Dostarlimab (TSR-042) is a programmed cell death protein 1 (PD-1) receptor immune checkpoint inhibitor that blocks interactions with PD-L1 and PD-L2, used in the study of endometrial cancer.
Cas No. 2022215-59-2
Customer service consultation
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $198 | In Stock | In Stock | |
| 5 mg | $579 | In Stock | In Stock | |
| 10 mg | $892 | - | In Stock | |
| 25 mg | $1,630 | - | In Stock | |
| 50 mg | $2,180 | - | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
Add to Cart
Add to Quotation
With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.
For research use only—not for human use. No sales to individuals. Use as intended only.
Batch Information
Select Batch
Purity:98.92% (SEC-HPLC)
Appearance:Liquid
Color:Transparent
Contact us for more batch information
Resource Download
Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
Antibody Information
Storage & Solubility Information
| Description | Dostarlimab (TSR-042) is a programmed cell death protein 1 (PD-1) receptor immune checkpoint inhibitor that blocks interactions with PD-L1 and PD-L2, used in the study of endometrial cancer. |
| Targets & IC50 | PD-1 (human):2.0 nM (EC50) |
| In vitro | Dostarlimab has a strong binding affinity with human and cynomolateral monkey PD-1 protein with Kd of 0.3 and 0.5 nM, respectively. Dostarlimab binds to PD-1 on the surface of recombinant human and cynomophobe monkey cells expressed on CHO-K1 cells with EC50 values of 2.0 and 3.4 nM, respectively. Dostarlimab effectively blocked PD-1/PD-L1 and PD-1/PD-L2 binding with IC50 values of 1.8 and 1.5 nM, respectively. Adding Dostarlimab to the SEB-stimulated PBMC resulted in increased IL-2 production with an EC50 of about 0.1 nM, suggesting that Dostarlimab induced T cell activation. [1] |
| In vivo | Dostarlimab(200μg/ pill twice weekly) inhibited tumor growth in the MDA-MB-436 breast cancer model. [1] |
| Synonyms | TSR-042, TSR042, GSK-4057190A, GSK4057190A, ANB011, ANB 011 |
| Reactivity | Human |
| Verified Activity | Immobilized human PD-1 Protein (His) at 2 μg/mL can bind Dostarlimab. The EC50 is 0.02062 μg/mL. |
| Application | Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Gene ID | |
| Uniprot ID | |
| Target | PDCD1/PD-1/CD279 |
| Molecular Weight | 144.18 kDa |
| Cas No. | 2022215-59-2 |
| Isotype | Human IgG4SP kappa |
| Recommended Isotype Control |
| Storage | Store at low temperature -20°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
Calculator
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Preview
Related Tags: Dostarlimab chemical structure | Dostarlimab in vivo | Dostarlimab in vitro | Dostarlimab molecular weight
Generate Quote
Catalog No.: Cas No.:
Add
| Size | Quantity | Unit Price | Amount | Operation |
|---|
Generate Quote
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2026 TargetMol Chemicals Inc. All Rights Reserved.