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CMPD1

🥰Excellent
Catalog No. T14988Cas No. 41179-33-3

CMPD1 is a non-ATP-competitive p38 MAPK-mediated MK2 phosphorylation inhibitor(apparent Ki (Kiapp): 330 nM).

CMPD1

CMPD1

🥰Excellent
Purity: 99.8%
Catalog No. T14988Cas No. 41179-33-3
CMPD1 is a non-ATP-competitive p38 MAPK-mediated MK2 phosphorylation inhibitor(apparent Ki (Kiapp): 330 nM).
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$31In StockIn Stock
5 mg$106In StockIn Stock
10 mg$163In StockIn Stock
25 mg$296In StockIn Stock
50 mg$466In StockIn Stock
100 mg$722In StockIn Stock
500 mg$1,690In StockIn Stock
1 mL x 10 mM (in DMSO)$116In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.8%
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Product Introduction

Bioactivity
Description
CMPD1 is a non-ATP-competitive p38 MAPK-mediated MK2 phosphorylation inhibitor(apparent Ki (Kiapp): 330 nM).
Targets&IC50
MK2:(Kiapp)330 nM
In vitro
CMPD1 exhibits selective activity within glioblastoma cells by inhibiting tubulin polymerization[3], crucial for cell division. Contrarily, it does not affect p38 MAPK-mediated phosphorylation of substrates MBP and ATF2, indicating specificity in its action. Furthermore, it induces mitotic arrest and apoptosis in U87 cells[1], highlighting its potential therapeutic implications in targeting cancer cell proliferation and survival.
Chemical Properties
Molecular Weight349.4
FormulaC22H20FNO2
Cas No.41179-33-3
SmilesOc1ccc(NC(=O)CCCc2ccc(cc2)-c2ccccc2F)cc1
Relative Density.1.229g/cm3
ColorWhite
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 55 mg/mL (157.41 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.72 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.8620 mL14.3102 mL28.6205 mL143.1025 mL
5 mM0.5724 mL2.8620 mL5.7241 mL28.6205 mL
10 mM0.2862 mL1.4310 mL2.8620 mL14.3102 mL
20 mM0.1431 mL0.7155 mL1.4310 mL7.1551 mL
50 mM0.0572 mL0.2862 mL0.5724 mL2.8620 mL
100 mM0.0286 mL0.1431 mL0.2862 mL1.4310 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

MK2 phosphorylationMK2Mitogen-activated protein kinase activated protein kinase 2MAPKAPK2 (MK2)MAPKAP kinase 2MAPK activated protein kinase 2MAP kinase activated protein kinase 2InhibitorinhibitCMPD-1CMPD1CMPD 1
Related Tags: buy CMPD1 | purchase CMPD1 | CMPD1 cost | order CMPD1 | CMPD1 chemical structure | CMPD1 in vitro | CMPD1 formula | CMPD1 molecular weight
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