Shopping Cart

Remove All
Your shopping cart is currently empty

CMPD1

Name: CMPD1
Brand: TargetMol
SKU: T14988
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T14988Cas No. 41179-33-3

CMPD1 is a non-ATP-competitive p38 MAPK-mediated MK2 phosphorylation inhibitor(apparent Ki (Kiapp): 330 nM).

CMPD1

🥰Excellent

Purity: 99.8%

Catalog No. T14988Cas No. 41179-33-3

CMPD1 is a non-ATP-competitive p38 MAPK-mediated MK2 phosphorylation inhibitor(apparent Ki (Kiapp): 330 nM).

Pack Size	Price	Availability
1 mg	$31	In Stock
5 mg	$106	In Stock
10 mg	$163	In Stock
25 mg	$296	In Stock
50 mg	$466	In Stock
100 mg	$722	In Stock
500 mg	$1,690	In Stock
1 mL x 10 mM (in DMSO)	$116	In Stock

Add to Cart

Add to Quotation

Bulk & Custom

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.8%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	CMPD1 is a non-ATP-competitive p38 MAPK-mediated MK2 phosphorylation inhibitor(apparent Ki (Kiapp): 330 nM).
Targets&IC50	MK2:(Kiapp)330 nM
In vitro	CMPD1 exhibits selective activity within glioblastoma cells by inhibiting tubulin polymerization[3], crucial for cell division. Contrarily, it does not affect p38 MAPK-mediated phosphorylation of substrates MBP and ATF2, indicating specificity in its action. Furthermore, it induces mitotic arrest and apoptosis in U87 cells[1], highlighting its potential therapeutic implications in targeting cancer cell proliferation and survival.

Chemical Properties

Molecular Weight	349.4
Formula	C₂₂H₂₀FNO₂
Cas No.	41179-33-3
Smiles	Oc1ccc(NC(=O)CCCc2ccc(cc2)-c2ccccc2F)cc1
Relative Density.	1.229g/cm3
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (157.41 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8620 mL	14.3102 mL	28.6205 mL	143.1025 mL
5 mM	0.5724 mL	2.8620 mL	5.7241 mL	28.6205 mL
10 mM	0.2862 mL	1.4310 mL	2.8620 mL	14.3102 mL
20 mM	0.1431 mL	0.7155 mL	1.4310 mL	7.1551 mL
50 mM	0.0572 mL	0.2862 mL	0.5724 mL	2.8620 mL
100 mM	0.0286 mL	0.1431 mL	0.2862 mL	1.4310 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc