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AN3661

🥰Excellent
Catalog No. T36649Cas No. 1268335-33-6

AN3661, a potent antimalarial lead compound, targets a Plasmodium falciparum cleavage and polyadenylation specificity factor homologue subunit 3 (PfCPSF3) and inhibits Plasmodium falciparum laboratory-adapted strains, Ugandan field isolates, and murine P. berghei and P. falciparum infections[1].

AN3661

AN3661

🥰Excellent
Catalog No. T36649Cas No. 1268335-33-6
AN3661, a potent antimalarial lead compound, targets a Plasmodium falciparum cleavage and polyadenylation specificity factor homologue subunit 3 (PfCPSF3) and inhibits Plasmodium falciparum laboratory-adapted strains, Ugandan field isolates, and murine P. berghei and P. falciparum infections[1].
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Product Introduction

Bioactivity
Description
AN3661, a potent antimalarial lead compound, targets a Plasmodium falciparum cleavage and polyadenylation specificity factor homologue subunit 3 (PfCPSF3) and inhibits Plasmodium falciparum laboratory-adapted strains, Ugandan field isolates, and murine P. berghei and P. falciparum infections[1].
In vitro
AN3661 is active at nanomolar (IC50=20-56 nM) concentrations against P. falciparum laboratory strains known to be sensitive (3D7) or resistant (W2, Dd2, K1, HB3, FCR3 and TM90C2B), and AN3661 is similarly active in ex vivo studies of fresh Ugandan field isolates (mean ex vivo IC50=64 nM). AN3661 shows minimal cytotoxicity against mammalian cell lines, with the CC50 60.5 μM against Jurkat cells, and all other CC50 values greater than the highest concentrations tested (25 μM or above)[1].AN3661 inhibits the stability of P. falciparum transcripts[1].
In vivo
AN3661 (50-200 mg/kg; p.o.; daily for 4 days) inhibits murine P. berghei infections with an ED90 (4 days) of 0.34 mg/kg[1]. When administered orally for 4 days starting on the third day of infection, the ED90 is 0.57 mg/kg 4 days post-initiation[1]. Animal Model: P. berghei-infected mice (malaria model)[1].
Chemical Properties
Molecular Weight206
FormulaC10H11BO4
Cas No.1268335-33-6
Relative Density.1.31 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 250 mg/mL (1213.59 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM4.8544 mL24.2718 mL48.5437 mL242.7184 mL
5 mM0.9709 mL4.8544 mL9.7087 mL48.5437 mL
10 mM0.4854 mL2.4272 mL4.8544 mL24.2718 mL
20 mM0.2427 mL1.2136 mL2.4272 mL12.1359 mL
50 mM0.0971 mL0.4854 mL0.9709 mL4.8544 mL
100 mM0.0485 mL0.2427 mL0.4854 mL2.4272 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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