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Anti-MAPKAPK3 Antibody (5K175)
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Catalog No. TMAY-01057
Alias MK-3, mitogen-activated protein kinase-activated protein kinase 3, MAPKAPK-3, MAPKAP-K3, MAPKAP3, 3PK
Anti-MAPKAPK3 Antibody (5K175) is a Mouse antibody targeting MAPKAPK3. Anti-MAPKAPK3 Antibody (5K175) can be used in IHC-P.
Anti-MAPKAPK3 Antibody (5K175)
Anti-MAPKAPK3 Antibody (5K175)
😃Good
Catalog No. TMAY-01057Alias MK-3, mitogen-activated protein kinase-activated protein kinase 3, MAPKAPK-3, MAPKAP-K3, MAPKAP3, 3PK
Anti-MAPKAPK3 Antibody (5K175) is a Mouse antibody targeting MAPKAPK3. Anti-MAPKAPK3 Antibody (5K175) can be used in IHC-P.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $198 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Mouse Monoclonal Application: IHC-P Reactivity: Human |
| Alias | MK-3, mitogen-activated protein kinase-activated protein kinase 3, MAPKAPK-3, MAPKAP-K3, MAPKAP3, 3PK |
| Ig Type | Mouse IgG2a |
| Clone | 5K175 |
| Reactivity | Human |
| Verified Activity | Immunochemical staining of human MAPKAPK3 in human skeletal muscle with mouse monoclonal antibody (1:60, formalin-fixed paraffin embedded sections). |
| Application | IHC-P |
| Recommended Dose | IHC-P: 1:50-1:200 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human MAPKAPK3/MK3 (rh MAPKAPK3/MK3; TMPY-04378; NP_004626.1; Met1-Gln382). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | The MAPKAP kinases are a group of MAP kinase substrates that are themselves kinases. In response to activation, the MAP kinases phosphorylate downstream components on a consensus Pro-X-Ser/Thr-Pro motif. Several kinases that contain this motif have been identified and serve as substrates for the ERK and p38 MAP kinases. Mitogen-activated protein (MAP) kinase-activated protein kinase 3, also known as MAPKAPK-3 and 3pK, is a member of the Ser/Thr protein kinase family. It is widely expressed in human tissues, with a higher expression level observed in the heart and skeletal muscle. No expression in the brain. MAPKAPK-3 is unique since it was shown to be activated by three members of the MAPK family, namely extracellular-signal-regulated kinase (ERK), p38, and Jun-N-terminal kinase (JNK). It is highly activated both by mitogens and by stress-inducing agents or proinflammatory cytokines and translocates to the cytoplasm from the nucleus. MAPKAPK-3 is exclusively activated via the classical MAPK cascade, while stress-induced activation of MAPKAPK-3 is mainly mediated by p38, however, the mechanism defining the specificity remains unknown. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein: Human MAPKAPK3/MK3 Protein (TMPY-04378) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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