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YAP-TEAD-IN-3

Name: YAP-TEAD-IN-3
Brand: TargetMol
SKU: T77725
Price: 328 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: IAG933) Copy Product Info

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Synonyms: IAG933

Catalog No. T77725 Copy Product Info

Purity: 98.71%

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YAP-TEAD-IN-3 (IAG933) belongs to small molecule inhibitors and is a TEAD-targeted YAP/TAZ-TEAD protein-protein interaction inhibitor (IC50 = 9 nM) with oral activity and selective inhibitory capability against all four TEAD isoforms. This compound is used in antitumor and pro-apoptosis research.

Cas No. 2714434-21-4

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Pack Size	Price	USA Stock	Global Stock
1 mg	$328	In Stock	In Stock
5 mg	$783	In Stock	In Stock
10 mg	$1,060	In Stock	In Stock
50 mg	$1,480	In Stock	In Stock
100 mg	$1,980	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:98.71%

Appearance:Solid

Color:White to Yellow

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COA HNMR HPLC

Product Introduction

Bioactivity

Description	YAP-TEAD-IN-3 (IAG933) belongs to small molecule inhibitors and is a TEAD-targeted YAP/TAZ-TEAD protein-protein interaction inhibitor (IC50 = 9 nM) with oral activity and selective inhibitory capability against all four TEAD isoforms. This compound is used in antitumor and pro-apoptosis research.
Targets & IC50	NCI-H2052 cells:0.048 μM, YAP-TEAD:9 nM, TEAD (MSTO-211H cells):11-26 nM
In vitro	Methods: Cells were treated with YAP-TEAD-IN-3 (IAG933) (0-1 μM) for 4 hours to detect the interaction between YAP/TAZ and TEAD isoforms and TEAD-driven transcriptional activity; MSTO211H and NCI-H226 cells were treated with YAP-TEAD-IN-3 (IAG933) (0.0001-10 μM) for 24 hours to detect TEAD target gene expression; Hippo-dependent mesothelioma cells were treated with YAP-TEAD-IN-3 (IAG933) (0.001-10 μM) for 72 hours to detect anti-proliferative activity. Results: YAP-TEAD-IN-3 (IAG933) directly inhibited the interaction between YAP/TAZ and all four TEAD isoforms, selectively suppressing TEAD transcriptional activity; YAP-TEAD-IN-3 (IAG933) dose-dependently inhibited TEAD target gene expression with IC50 values of 11-26 nM; YAP-TEAD-IN-3 (IAG933) demonstrated potent anti-proliferative activity in mesothelioma cells with GI50 of 13-91 nM.[1]
Synonyms	IAG933

Chemical Properties

Molecular Weight	529.96
Formula	C₂₇H₂₆ClF₂N₃O₄
Cas No.	2714434-21-4
Smiles	OCCOC1=C([C@@]([C@@]2=C(Cl)C(F)=CC3=C2C[C@@]([C@@H]4CCCN4)(C5=CC=CC=C5)O3)=C(C(NC)=O)C=N1)F
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 120 mg/mL (226.43 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8869 mL	9.4347 mL	18.8693 mL	94.3467 mL
5 mM	0.3774 mL	1.8869 mL	3.7739 mL	18.8693 mL
10 mM	0.1887 mL	0.9435 mL	1.8869 mL	9.4347 mL
20 mM	0.0943 mL	0.4717 mL	0.9435 mL	4.7173 mL
50 mM	0.0377 mL	0.1887 mL	0.3774 mL	1.8869 mL
100 mM	0.0189 mL	0.0943 mL	0.1887 mL	0.9435 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.