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YAP-TEAD-IN-3

Name: YAP-TEAD-IN-3
Brand: TargetMol
SKU: T77725
Price: 328 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T77725Cas No. 2714434-21-4

Alias IAG933

YAP-TEAD-IN-3 is an inhibitor of YAP/TAZ-TEAD interactions with an IC50 of 9 nM for Avi-human TEAD (4217-434). YAP-TEAD-IN-3 inhibits YAP reporter gene expression (IC50 = 0.048 μM) and NCI-H2052 cell proliferation (IC50 = 0.048 μM).

YAP-TEAD-IN-3

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Purity: 98.71%

Catalog No. T77725Alias IAG933Cas No. 2714434-21-4

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$328	In Stock	In Stock
5 mg	$783	In Stock	In Stock
10 mg	$1,060	In Stock	In Stock
50 mg	$1,480	In Stock	In Stock
100 mg	$1,980	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.71%

Appearance:Solid

Color:White to Yellow

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	YAP-TEAD-IN-3 is an inhibitor of YAP/TAZ-TEAD interactions with an IC50 of 9 nM for Avi-human TEAD (4217-434). YAP-TEAD-IN-3 inhibits YAP reporter gene expression (IC50 = 0.048 μM) and NCI-H2052 cell proliferation (IC50 = 0.048 μM).
Targets&IC50	NCI-H2052 cells:0.048 μM, TEAD (MSTO-211H cells):11-26 nM, YAP-TEAD:9 nM
Synonyms	IAG933

Chemical Properties

Molecular Weight	529.96
Formula	C₂₇H₂₆ClF₂N₃O₄
Cas No.	2714434-21-4
Smiles	OCCOC1=C([C@@]([C@@]2=C(Cl)C(F)=CC3=C2C[C@@]([C@@H]4CCCN4)(C5=CC=CC=C5)O3)=C(C(NC)=O)C=N1)F
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 120 mg/mL (226.43 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8869 mL	9.4347 mL	18.8693 mL	94.3467 mL
5 mM	0.3774 mL	1.8869 mL	3.7739 mL	18.8693 mL
10 mM	0.1887 mL	0.9435 mL	1.8869 mL	9.4347 mL
20 mM	0.0943 mL	0.4717 mL	0.9435 mL	4.7173 mL
50 mM	0.0377 mL	0.1887 mL	0.3774 mL	1.8869 mL
100 mM	0.0189 mL	0.0943 mL	0.1887 mL	0.9435 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc