Shopping Cart

Remove All
Your shopping cart is currently empty

YAP-TEAD-IN-3

Name: YAP-TEAD-IN-3
Brand: TargetMol
SKU: T77725
Price: 328 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T77725Cas No. 2714434-21-4

Alias IAG933

YAP-TEAD-IN-3 is an inhibitor of YAP/TAZ-TEAD interactions with an IC50 of 9 nM for Avi-human TEAD (4217-434). YAP-TEAD-IN-3 inhibits YAP reporter gene expression (IC50 = 0.048 μM) and NCI-H2052 cell proliferation (IC50 = 0.048 μM).

YAP-TEAD-IN-3

🥰Excellent

Purity: 98.71%

Catalog No. T77725Alias IAG933Cas No. 2714434-21-4

Pack Size	Price	Availability
1 mg	$328	In Stock
5 mg	$783	In Stock
10 mg	$1,060	In Stock
50 mg	$1,480	In Stock
100 mg	$1,980	In Stock

Add to Cart

Add to Quotation

Bulk & Custom

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:98.71%

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	YAP-TEAD-IN-3 is an inhibitor of YAP/TAZ-TEAD interactions with an IC50 of 9 nM for Avi-human TEAD (4217-434). YAP-TEAD-IN-3 inhibits YAP reporter gene expression (IC50 = 0.048 μM) and NCI-H2052 cell proliferation (IC50 = 0.048 μM).
Targets&IC50	TEAD (MSTO-211H cells):11-26 nM, YAP-TEAD:9 nM, NCI-H2052 cells:0.048 μM
Synonyms	IAG933

Chemical Properties

Molecular Weight	529.96
Formula	C₂₇H₂₆ClF₂N₃O₄
Cas No.	2714434-21-4
Smiles	O=C(NC)C1=CN=C(OCCO)C(F)=C1C2=C3C[C@@]([C@H]4NCCC4)(OC3=CC(F)=C2Cl)C5=CC=CC=C5
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 120 mg/mL (226.43 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8869 mL	9.4347 mL	18.8693 mL	94.3467 mL
5 mM	0.3774 mL	1.8869 mL	3.7739 mL	18.8693 mL
10 mM	0.1887 mL	0.9435 mL	1.8869 mL	9.4347 mL
20 mM	0.0943 mL	0.4717 mL	0.9435 mL	4.7173 mL
50 mM	0.0377 mL	0.1887 mL	0.3774 mL	1.8869 mL
100 mM	0.0189 mL	0.0943 mL	0.1887 mL	0.9435 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc