Y1 receptor antagonist 1 (H 409-22 isomer) is the active isomer of H-409/22, a neuropeptide Y (NPY) Y1 receptor antagonist that dose-dependently antagonizes the vascular response to exogenous and endogenous NPY in pigs. lagodeoxycholic acid (H 409-22 isomer) is the active isomer of H-409/22, an antagonist of neuropeptide Y (NPY) Y1 receptor.

24 wild-type male Wistar rats were injected with Y1 receptor antagonist 1 (1×10-4M, dissolved in hyaluronic acid (HA)) into the tibial intramedullary area. Y1 receptor antagonist 1 may have the ability to regulate local bone mineral density (BMD). ) and bone formation potential. Y1 receptor antagonist 1 causes new bone formation in trabecular bone when applied topically [1]; Y1 receptor antagonist 1 (100-200 nmol) is dissolved in sterile water and infused with 5-7 μl of saline 15 minutes before use. The volume of Y1 receptor antagonist 1 was infused into guinea pigs. Among them, a dose of 200 nmol of Y1 receptor antagonist 1 was able to inhibit the feeding response to NPY, while a lower dose of H 409/22 was ineffective, and Y1 receptor antagonist 1 had a moderate stimulating effect on feeding [2] ; 82 evaluable male patients were enrolled in a randomized, double-blind, two-way crossover study, low-dose (6.7 μg/kg/min; n=59) and high-dose (13.3 μg/kg/min; n=23) Y1 receptor antagonist Y1 receptor antagonist 1 can attenuate the increase in blood pressure during exercise but does not affect exercise-induced ischemic parameters in patients with coronary artery disease when infused for 2 hours or placebo [3].