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Mazdutide acetate（2259884-03-0 free base）

Catalog No. T78097L

Synonyms: Mazdutide acetate（2259884-03-0 free base）, OXM-3 acetate, LY-3305677 acetate, IBI-362 acetate

Mazdutide acetate is a potent co-agonist of glucagon-like peptide (GLP-1R) and glucagon receptor (GCGR), a gastrin-regulating hormone analog.Mazdutide acetate stimulates insulin secretion from mouse pancreatic islets, and can be used in studies of obesity and type 2 diabetes (T2D).

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Mazdutide acetate（2259884-03-0 free base） Chemical Structure

Mazdutide acetate（2259884-03-0 free base）, CAS N/A

Pack Size	Availability	Price/USD
1 mg	In stock	$ 89.00
5 mg	In stock	$ 272.00
10 mg	In stock	$ 455.00
25 mg	In stock	$ 736.00
50 mg	In stock	$ 1,172.00

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Purity: 98.41%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Mazdutide acetate is a potent co-agonist of glucagon-like peptide (GLP-1R) and glucagon receptor (GCGR), a gastrin-regulating hormone analog.Mazdutide acetate stimulates insulin secretion from mouse pancreatic islets, and can be used in studies of obesity and type 2 diabetes (T2D).
In vitro	In oral glucose tolerance tests of diet-induced obese (DIO) and streptozotocin-induced diabetic mice, a single subcutaneous (SC) dose of Mazdutide acetate(15, 30 nmol/kg;) significantly reduced glucose area under the curve by up to 65%[3].

Synonyms	Mazdutide acetate（2259884-03-0 free base）, OXM-3 acetate, LY-3305677 acetate, IBI-362 acetate
Molecular Weight	N/A

Storage

store at low temperature,keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Chen T, et al. The Design and Optimization of Monomeric Multitarget Peptides for the Treatment of Multifactorial Diseases. J Med Chem. 2022 Mar 10;65(5):3685-3705. 2. Jiang H, et al. A phase 1b randomised controlled trial of a glucagon-like peptide-1 and glucagon receptor dual agonist IBI362 (LY3305677) in Chinese patients with type 2 diabetes. Nat Commun. 2022 Jun 24;13(1):3613. 3. Chen Y,et al. 682-P: novel dual glucagon and glucagon-like peptide-1 receptor agonist LY3305677 improves glucose control, reduces body weight, and increases energy expenditure in mice[J]. Diabetes, 2021, 70(Supplement_1).

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Mazdutide acetate（2259884-03-0 free base） GPCR/G Protein Glucagon Receptor OXM-3 acetate LY-3305677 acetate IBI-362 acetate inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.