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PI3K/Akt/CREB activator 1

Name: PI3K/Akt/CREB activator 1
Brand: TargetMol
SKU: T72227
Price: 67 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T72227Cas No. 2708177-73-3

PI3K/Akt/CREB activator 1 (AE-18) is a selective inducible nitric oxide synthase (iNOS) inhibitor that crosses the blood-brain barrier, reduces infarct size and restores blood supply deficits after ischemia-reperfusion in rats, and is used in studies of vascular dementia and Parkinson's disease.

PI3K/Akt/CREB activator 1

🥰Excellent

Catalog No. T72227Cas No. 2708177-73-3

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
2 mg	$67	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	PI3K/Akt/CREB activator 1 (AE-18) is a selective inducible nitric oxide synthase (iNOS) inhibitor that crosses the blood-brain barrier, reduces infarct size and restores blood supply deficits after ischemia-reperfusion in rats, and is used in studies of vascular dementia and Parkinson's disease.
In vitro	PI3K/Akt/CREB activator 1 (Compound AE-18) (10 and 20 μM; 48 hr treatment) enhances BDNF expression in Neuro-2a cells through activation of the PI3K/Akt/CREB pathway, which promotes the formation of neurites and cell proliferation. Treatment of neurons with 10 and 20 μM PI3K/Akt/CREB activator 1 enhances the differentiation of cultured hippocampal neurons and promotes axonal and dendritic polarity formation through the PI3K/Akt signaling pathway. [1]
In vivo	In male Sprague-Dawley rats in a chronic cerebral hypoperfusion (CCH) model, gavage of 5 and 10 mg/kg PI3K/Akt/CREB activator 1 promoted the recovery of cerebral blood flow (CBF) after bilateral common carotid artery ligation (BCCAO). PI3K/Akt/CREB activator 1 (5 and 10 mg/kg; by gavage; for 5 consecutive days) attenuated learning and memory impairments in a rat model of CCH, while alleviating hippocampal pathology damage caused by BCCAO. [1]

Chemical Properties

Molecular Weight	381.32
Formula	C₁₉H₁₅F₄NO₃
Cas No.	2708177-73-3
Smiles	C([C@H](NC(/C=C/C1=CC=C(C(F)(F)F)C=C1)=O)C(O)=O)C2=CC=C(F)C=C2

Storage & Solubility Information

Storage

store at low temperature | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 200 mg/mL (524.49 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (13.11 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6225 mL	13.1123 mL	26.2247 mL	131.1235 mL
5 mM	0.5245 mL	2.6225 mL	5.2449 mL	26.2247 mL
10 mM	0.2622 mL	1.3112 mL	2.6225 mL	13.1123 mL
20 mM	0.1311 mL	0.6556 mL	1.3112 mL	6.5562 mL
50 mM	0.0524 mL	0.2622 mL	0.5245 mL	2.6225 mL
100 mM	0.0262 mL	0.1311 mL	0.2622 mL	1.3112 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc