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PI3K/Akt/CREB activator 1

Name: PI3K/Akt/CREB activator 1
Brand: TargetMol
SKU: T72227
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T72227Cas No. 2708177-73-3

PI3K/Akt/CREB activator 1 (AE-18) is a selective inducible nitric oxide synthase (iNOS) inhibitor that crosses the blood-brain barrier, reduces infarct size and restores blood supply deficits after ischemia-reperfusion in rats, and is used in studies of vascular dementia and Parkinson's disease.

PI3K/Akt/CREB activator 1

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Catalog No. T72227Cas No. 2708177-73-3

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
2 mg	$99	-	In Stock
1 mL x 10 mM (in DMSO)	$29	6-8 weeks	6-8 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Appearance:Oil

Color:Transparent

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Product Introduction

Bioactivity

Description	PI3K/Akt/CREB activator 1 (AE-18) is a selective inducible nitric oxide synthase (iNOS) inhibitor that crosses the blood-brain barrier, reduces infarct size and restores blood supply deficits after ischemia-reperfusion in rats, and is used in studies of vascular dementia and Parkinson's disease.
In vitro	PI3K/Akt/CREB activator 1 (Compound AE-18) (10 and 20 μM; 48 hr treatment) enhances BDNF expression in Neuro-2a cells through activation of the PI3K/Akt/CREB pathway, which promotes the formation of neurites and cell proliferation. Treatment of neurons with 10 and 20 μM PI3K/Akt/CREB activator 1 enhances the differentiation of cultured hippocampal neurons and promotes axonal and dendritic polarity formation through the PI3K/Akt signaling pathway. [1]
In vivo	In male Sprague-Dawley rats in a chronic cerebral hypoperfusion (CCH) model, gavage of 5 and 10 mg/kg PI3K/Akt/CREB activator 1 promoted the recovery of cerebral blood flow (CBF) after bilateral common carotid artery ligation (BCCAO). PI3K/Akt/CREB activator 1 (5 and 10 mg/kg; by gavage; for 5 consecutive days) attenuated learning and memory impairments in a rat model of CCH, while alleviating hippocampal pathology damage caused by BCCAO. [1]

Chemical Properties

Molecular Weight	381.32
Formula	C₁₉H₁₅F₄NO₃
Cas No.	2708177-73-3
Smiles	C([C@H](NC(/C=C/C1=CC=C(C(F)(F)F)C=C1)=O)C(O)=O)C2=CC=C(F)C=C2

Storage & Solubility Information

Storage

store at low temperature | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 200 mg/mL (524.49 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (13.11 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6225 mL	13.1123 mL	26.2247 mL	131.1235 mL
5 mM	0.5245 mL	2.6225 mL	5.2449 mL	26.2247 mL
10 mM	0.2622 mL	1.3112 mL	2.6225 mL	13.1123 mL
20 mM	0.1311 mL	0.6556 mL	1.3112 mL	6.5562 mL
50 mM	0.0524 mL	0.2622 mL	0.5245 mL	2.6225 mL
100 mM	0.0262 mL	0.1311 mL	0.2622 mL	1.3112 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc