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MS023 dihydrochloride

Name: MS023 dihydrochloride
Brand: TargetMol
SKU: T61338
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T61338Cas No. 1992047-64-9

Alias MS023 2HCl

MS023 dihydrochloride (MS023 2HCl) is a selective, cytosolic and highly potent inhibitor of human type I protein arginine methyltransferases (PRMTs) with antitumour activity, inhibits PRMT1, PRMT3, PRMT4, PRMT6, and PRMT8, and increases the proliferative capacity of isolated cultured MuSC. It can be used to study breast cancer.

MS023 dihydrochloride

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Purity: 99.52%

Catalog No. T61338Alias MS023 2HClCas No. 1992047-64-9

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$77	In Stock	In Stock
10 mg	$108	In Stock	In Stock
25 mg	$179	In Stock	In Stock
50 mg	$266	In Stock	In Stock
100 mg	$395	-	In Stock
1 mL x 10 mM (in DMSO)	$39	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.52%

Appearance:Solid

Color:Yellow

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	MS023 dihydrochloride (MS023 2HCl) is a selective, cytosolic and highly potent inhibitor of human type I protein arginine methyltransferases (PRMTs) with antitumour activity, inhibits PRMT1, PRMT3, PRMT4, PRMT6, and PRMT8, and increases the proliferative capacity of isolated cultured MuSC. It can be used to study breast cancer.
In vitro	MS023 dihydrochloride (1-1000 nM) effectively and concentration-dependently reduces PRMT1 methyltransferase activity in MCF7 cells[1].
In vivo	In NOD-scid IL2Rgnull (NSG) mice bearing primary MLL-r ALL cells, combinatorial treatment with MS023 dihydrochloride (160 mg/kg, ip) and PKC412 (100 mg/kg, i.g.) for 4 weeks extended the survival of leukemic mice compared to single treatments[2].
Synonyms	MS023 2HCl

Chemical Properties

Molecular Weight	360.32
Formula	C₁₇H₂₇Cl₂N₃O
Cas No.	1992047-64-9
Smiles	Cl.Cl.CC(C)Oc1ccc(cc1)-c1c[nH]cc1CN(C)CCN

Storage & Solubility Information

Storage

store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 20 mg/mL (55.51 mM), Sonication is recommended.

DMSO: 100 mg/mL (277.53 mM), Sonication is recommended.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7753 mL	13.8766 mL	27.7531 mL	138.7655 mL
5 mM	0.5551 mL	2.7753 mL	5.5506 mL	27.7531 mL
10 mM	0.2775 mL	1.3877 mL	2.7753 mL	13.8766 mL
20 mM	0.1388 mL	0.6938 mL	1.3877 mL	6.9383 mL
50 mM	0.0555 mL	0.2775 mL	0.5551 mL	2.7753 mL

DMSO

	1mg	5mg	10mg	50mg
100 mM	0.0278 mL	0.1388 mL	0.2775 mL	1.3877 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc