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NR-160

Name: NR-160
Brand: TargetMol
SKU: T37068
Rating: 4.5 (1 reviews)

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Catalog No. T37068Cas No. 2484895-50-1

NR-160 is a selective HDAC6 inhibitor (IC₅₀=30 nM) with low cytotoxicity against leukemia cell lines.

NR-160

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Catalog No. T37068Cas No. 2484895-50-1

NR-160 is a selective HDAC6 inhibitor (IC₅₀=30 nM) with low cytotoxicity against leukemia cell lines.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$287	35 days	35 days
5 mg	$1,290	35 days	35 days
10 mg	$2,290	35 days	35 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Appearance:Solid

Color:White

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Product Introduction

Bioactivity

Description	NR-160 is a selective HDAC6 inhibitor (IC₅₀=30 nM) with low cytotoxicity against leukemia cell lines.
Targets&IC50	HDAC6:30 nM
In vitro	Treatment of cells with NR-160 (Compound 6I) at concentrations of 2.5 μmol/L and 5 μmol/L for 24 hours induced acetylation modification of α-tubulin (acetylated α-tubulin) [1]. When applied at concentrations ranging from 1 to 50 μmol/L for 24 hours, this compound exhibited weak cytotoxicity against leukemia cell lines, with all half-maximal inhibitory concentrations (IC₅₀) above 20 μmol/L [1]. In addition, treatment of HL-60 cells with 2.5 μmol/L and 5 μmol/L NR-160 for 24 hours significantly enhanced the cytotoxic induction effects of Bortezomib, Epirubicin and Daunorubicin on these cells [1]. Cell viability assays demonstrated that NR-160 exerted an inhibitory effect on leukemia cell lines [1], with IC₅₀ values of 49.4 μM, 51.8 μM, 42.4 μM, 32.1 μM, 42.9 μM, 22.5 μM and 41.6 μM against TALL-1, HSB-2, MOLT-4, Jurkat, HL-60, SUP-B15 and K562 cells, respectively.

Chemical Properties

Molecular Weight	510.47
Formula	C₂₅H₂₁F₃N₆O₃
Cas No.	2484895-50-1
Smiles	O=C(NO)C1=CC=C(C=C1)CN(C(=O)C=2C=CC=CC2C(F)(F)F)CC3=NN=NN3CC=4C=CC=CC4

Storage & Solubility Information

Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Solubility Information	Ethanol: 0.5 mg/mL (0.98 mM), Sonication is recommended. DMSO: 10 mg/mL (19.59 mM), Sonication is recommended. DMF: 15 mg/mL (29.38 mM), Sonication is recommended.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc