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Vorasidenib

Name: Vorasidenib
Brand: TargetMol
SKU: T7307
Price: 48 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T7307Cas No. 1644545-52-7

Alias PVM/MA, AG-881

Vorasidenib (PVM/MA) is an inhibitor of mutant isocitrate dehydrogenase (IDH; IC50s = 31.9 and 31.7 nM for IDH1R132H and IDH2R140Q, respectively)

Vorasidenib

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Purity: 99.57%

Catalog No. T7307Alias PVM/MA, AG-881Cas No. 1644545-52-7

Vorasidenib (PVM/MA) is an inhibitor of mutant isocitrate dehydrogenase (IDH; IC50s = 31.9 and 31.7 nM for IDH1R132H and IDH2R140Q, respectively)

Pack Size	Price	Availability
1 mg	$48	In Stock
2 mg	$72	In Stock
5 mg	$122	In Stock
10 mg	$198	In Stock
25 mg	$378	In Stock
50 mg	$568	In Stock
100 mg	$815	In Stock
1 mL x 10 mM (in DMSO)	$109	In Stock

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Batch Information

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Purity:99.57%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Vorasidenib (PVM/MA) is an inhibitor of mutant isocitrate dehydrogenase (IDH; IC50s = 31.9 and 31.7 nM for IDH1R132H and IDH2R140Q, respectively)
Targets&IC50	IDH1 (R132H):31.9 nM , IDH2 (R140Q):31.7 nM
In vivo	Vorsidenib reduces tumor growth in a TS603-IDH1R132H mouse xenograft model when administered at a dose of 50 mg/kg.
Synonyms	PVM/MA, AG-881

Chemical Properties

Molecular Weight	414.74
Formula	C₁₄H₁₃ClF₆N₆
Cas No.	1644545-52-7
Smiles	C[C@@H](Nc1nc(N[C@H](C)C(F)(F)F)nc(n1)-c1cccc(Cl)n1)C(F)(F)F
Relative Density.	1.491 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (241.11 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4111 mL	12.0557 mL	24.1115 mL	120.5575 mL
5 mM	0.4822 mL	2.4111 mL	4.8223 mL	24.1115 mL
10 mM	0.2411 mL	1.2056 mL	2.4111 mL	12.0557 mL
20 mM	0.1206 mL	0.6028 mL	1.2056 mL	6.0279 mL
50 mM	0.0482 mL	0.2411 mL	0.4822 mL	2.4111 mL
100 mM	0.0241 mL	0.1206 mL	0.2411 mL	1.2056 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc