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FSCPX

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Catalog No. T39039Cas No. 156547-56-7

FSCPX is a potent and selective irreversible antagonist of the A1 adenosine receptor (A1AR), exhibiting low nanomolar binding potency. It can effectively decrease the interstitial adenosine level in the guinea pig atrium, thereby modifying the effect of [NBTI], a nucleoside transport inhibitor.

FSCPX

FSCPX

😃Good
Purity: 99.4%
Catalog No. T39039Cas No. 156547-56-7
FSCPX is a potent and selective irreversible antagonist of the A1 adenosine receptor (A1AR), exhibiting low nanomolar binding potency. It can effectively decrease the interstitial adenosine level in the guinea pig atrium, thereby modifying the effect of [NBTI], a nucleoside transport inhibitor.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$79In StockIn Stock
5 mg$201In StockIn Stock
10 mg$302In StockIn Stock
25 mg$512In StockIn Stock
50 mg$685In StockIn Stock
100 mg$917-In Stock
200 mg$1,230-In Stock
1 mL x 10 mM (in DMSO)$83In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.4%
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Product Introduction

Bioactivity
Description
FSCPX is a potent and selective irreversible antagonist of the A1 adenosine receptor (A1AR), exhibiting low nanomolar binding potency. It can effectively decrease the interstitial adenosine level in the guinea pig atrium, thereby modifying the effect of [NBTI], a nucleoside transport inhibitor.
Targets&IC50
DDT1 MF2 cells:11.8±3.2 nM
In vitro
FSCPX (2-20 μM ; 48 h) reverses the upregulation of HSP27 mRNA and protein in A1AR-overexpressing LLC-PK1 cells without an effect on the mRNA or protein for HSP70.[3]
FSCPX (20 μM ; 48 h) attenuates protection from necrosis and apoptosis in A1AR-overexpressing LLC-PK1 cells.[3]
Chemical Properties
Molecular Weight506.55
FormulaC23H27FN4O6S
Cas No.156547-56-7
SmilesCCCn1c(=O)n(CCCOC(=O)c2ccc(cc2)S(F)(=O)=O)c2[nH]c(nc2c1=O)C1CCCC1
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 45 mg/mL (88.84 mM), Sonication and heating to 60℃ are recommended.
In Vivo Formulation
10% DMSO+90% Corn Oil: 2 mg/mL (3.95 mM), Sonication is recommeded.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.9741 mL9.8707 mL19.7414 mL98.7069 mL
5 mM0.3948 mL1.9741 mL3.9483 mL19.7414 mL
10 mM0.1974 mL0.9871 mL1.9741 mL9.8707 mL
20 mM0.0987 mL0.4935 mL0.9871 mL4.9353 mL
50 mM0.0395 mL0.1974 mL0.3948 mL1.9741 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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μL
2 Enter the in vivo formulation:
% DMSO
%
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% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

FSCPXAdenosineReceptorAdenosine receptorAdenosine Receptor
Related Tags: buy FSCPX | purchase FSCPX | FSCPX cost | order FSCPX | FSCPX chemical structure | FSCPX in vitro | FSCPX formula | FSCPX molecular weight
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