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Cell Activation CD Proteins

Markers of T cell activation include CD69, CD71 and CD25 (also a marker for Treg cells), and HLA-DR (a marker of human T cell activation). CTLA-4 expression is also up-regulated on activated T cells, which in turn outcompetes CD28 for binding to the B7 proteins. This is a checkpoint mechanism to prevent over activation of the T cell. In dendritic cells, the most important CD markers of activation are CD80, CD86 and CD83. CD40 is already expressed in most immature dendritic cells, although their expression intensity increases strongly, following the activation.

  • CD83 Protein, Human, Recombinant (hFc)
    TMPJ-01070
    CD83 antigen is a single-pass type I membrane protein which contains one Ig-like V-type (immunoglobulin-like) domain. CD83 is expressed by activated lymphocytes, Langerhans cells and interdigitating reticulum cells. It contains one Ig-like V-type (immunoglobulin-like) domain. , the soluble CD83 has the opposite effect and has an immune inhibitory capacity. Due to its immune inhibitory function, CD83 may play a significant role in antigen presentation or the cellular interactions that follow lymphocyte activation.
    • $116
    7-10 days
    Size
    QTY
  • CD27 Ligand/CD70 Trimer Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated
    TMPK-00080
    CD70, also named CD27 ligand (CD27L), is a type II transmembrane glycoprotein belonging to the TNF superfamily (TNFSF) and has been designated TNFSF7.  CD70 is a cytokine that binds to CD27. Plays a role in T-cell activation. Induces the proliferation of costimulated T-cells and enhances the generation of cytolytic T-cells. CD27 Ligand/CD70 Trimer Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with N-His tag. The predicted molecular weight is 51.8 kDa and the accession number is P32970-1.
    • $814
    7-10 days
    Size
    QTY
  • BTLA Protein, Rhesus, Recombinant (hFc)
    TMPY-04047
    BTLA Protein, Rhesus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 41.4 kDa and the accession number is A0A8J8XCU2.
    • $600
    7-10 days
    Size
    QTY
  • Siglec-3/CD33 Protein, Human, Recombinant, PE conjugated
    TMPY-05572
    Siglec-3/CD33 Protein, Human, Recombinant, PE conjugated is expressed in HEK293 mammalian cells. The accession number is AAH28152.1.
    • $385
    7-10 days
    Size
    QTY
  • BTLA Protein, Mouse, Recombinant (His)
    TMPY-06923
    BTLA Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 21.54 kDa and the accession number is AAI08964.1.
    • $600
    7-10 days
    Size
    QTY
  • CD27 Ligand/CD70 Protein, Mouse, Recombinant (His)
    TMPJ-00075
    CD27 Ligand (CD70) is a 30 kDa type 2 transmembrane glycoproteinis that belongs to the tumor necrosis factor (TNF) ligand family.Human CD27 Ligand extracellular region is 64% aa identical to mouse and rat CD27 Ligand extracellular regions. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis.
    • $86
    7-10 days
    Size
    QTY
  • B7-H2/ICOSLG Protein, Human, Recombinant (His & Avi), Biotinylated
    TMPK-00193
    B7-H2, also known as B7-related protein (B7RP1), ICOS Ligand, and CD275, is an approximately 60 kDa transmembrane glycoprotein in the B7 family of immune regulatory molecules. B7-H2 is a ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. B7-H2/ICOSLG Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 29.5 kDa and the accession number is O75144.
    • $814
    7-10 days
    Size
    QTY
  • CD83 Protein, Cynomolgus, Recombinant (His)
    TMPK-00500
    CD83 is a member of the immunoglobulin (Ig) superfamily and is expressed in membrane bound or soluble forms. Membrane CD83 (mCD83) can be detected on a variety of activated immune cells, although it is most highly and stably expressed by mature dendritic cells (DC). While CD83 is emerging as a promising immune modulator with therapeutic potential, some important aspects such as its ligand/s, intracellular signaling pathways and modulators of its expression are unclear.
    • $487
    7-10 days
    Size
    QTY
  • BTLA Protein, Human, Recombinant (His & Avi)
    TMPK-01066
    B- and T-lymphocyte attenuator (BTLA; CD272) is a 35 kDa type I transmembrane glycoprotein in the CD28 family of T cell costimulatory molecules. BTLA is a inhibitory receptor on lymphocytes that negatively regulates antigen receptor signaling via PTPN6/SHP-1 and PTPN11/SHP-2. BTLA may interact in cis (on the same cell) or in trans (on other cells) with TNFRSF14. BTLA Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 16.7 kDa and the accession number is Q7Z6A9-1.
    • $511
    7-10 days
    Size
    QTY
  • CD83 Protein, Human, Recombinant (His)
    TMPY-01829
    CD83 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 15.5 kDa and the accession number is Q01151-1.
    • $386
    In Stock
    Size
    QTY
  • 2B4/CD244 Protein, Human, Recombinant (His)
    TMPY-01568
    2B4/CD244 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 23.8 kDa and the accession number is Q9BZW8-2.
    • $600
    7-10 days
    Size
    QTY
  • CD83 Protein, Rat, Recombinant (hFc)
    TMPY-03005
    CD83 Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 39.4 kDa and the accession number is B2GV95.
    • $600
    7-10 days
    Size
    QTY
  • CD83 Protein, Rat, Recombinant (His)
    TMPY-03138
    CD83 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 13.9 kDa and the accession number is B2GV95.
    • $600
    7-10 days
    Size
    QTY
  • BTLA Protein, Mouse, Recombinant (hFc)
    TMPY-03186
    BTLA Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 43.75 kDa and the accession number is AAI08964.1.
    • $600
    7-10 days
    Size
    QTY
  • Siglec-3/CD33 Protein, Human, Recombinant, FITC conjugated
    TMPY-05571
    Siglec-3/CD33 Protein, Human, Recombinant, FITC conjugated is expressed in HEK293 mammalian cells. The accession number is AAH28152.1.
    • $385
    7-10 days
    Size
    QTY
  • BTLA Protein, Human, Recombinant (isoform 1,mFc)
    TMPY-06829
    BTLA Protein, Human, Recombinant (isoform 1,mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 40.56 kDa and the accession number is NP_861445.4.
    • $600
    7-10 days
    Size
    QTY
  • BTLA Protein, Human, Recombinant (His & Avi), Biotinylated
    TMPY-06913
    BTLA Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 17 kDa.
    • $600
    7-10 days
    Size
    QTY
  • BTLA Protein, Human, Recombinant (isoform1,hFc)
    TMPY-06930
    BTLA Protein, Human, Recombinant (isoform1,hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 40.47 kDa and the accession number is NP_861445.4.
    • $600
    7-10 days
    Size
    QTY
  • CD27 Ligand/CD70 Trimer Protein, Human, Recombinant (His), FITC-Labeled
    TMPK-00078
    CD70, also named CD27 ligand (CD27L), is a type II transmembrane glycoprotein belonging to the TNF superfamily (TNFSF) and has been designated TNFSF7.  CD70 is a cytokine that binds to CD27. Plays a role in T-cell activation. Induces the proliferation of costimulated T-cells and enhances the generation of cytolytic T-cells. CD27 Ligand/CD70 Trimer Protein, Human, Recombinant (His), FITC-Labeled is expressed in HEK293 mammalian cells with N-His tag. The predicted molecular weight is 51.8 kDa and the accession number is P32970-1.
    • $1,400
    7-10 days
    Size
    QTY
  • B7-H2/ICOSLG Protein, Cynomolgus, Recombinant (His)
    TMPK-01264
    B7-H2, also known as B7-related protein (B7RP1), ICOS Ligand, and CD275, is an approximately 60 kDa transmembrane glycoprotein in the B7 family of immune regulatory molecules. B7-H2 is a ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. B7-H2/ICOSLG Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 27.7 kDa and the accession number is XP_005548617.1.
    • $418
    7-10 days
    Size
    QTY
  • RP105/CD180 Protein, Mouse, Recombinant (His)
    TMPY-01667
    RP105/CD180 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 69.4 kDa and the accession number is Q62192.
    • $600
    7-10 days
    Size
    QTY
  • CD83 Protein, Mouse, Recombinant (His)
    TMPY-02156
    CD83 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 13.6 kDa and the accession number is O88324.
    • $600
    7-10 days
    Size
    QTY
  • CD83 Protein, Cynomolgus, Rhesus, Recombinant (hFc)
    TMPY-03378
    CD83 Protein, Cynomolgus, Rhesus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 41 kDa and the accession number is F6WX37.
    • $600
    7-10 days
    Size
    QTY
  • BTLA Protein, Human, Recombinant (mFc)
    TMPY-05828
    BTLA Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 40.09 kDa and the accession number is AAP44003.1.
    • $4,570
    7-10 days
    Size
    QTY
  • 2B4/CD244 Protein, Human, Recombinant (aa 22-221, His & Avi), Biotinylated
    TMPK-00237
    2B4 (CD244) is expressed by memory-phenotype CD8() T cells and all natural killer (NK) cells. The ligand for 2B4, CD48, is expressed on hematopoietic cells. 2B4 is conserved in humans and mice, and a number of reports have linked 2B4 with activation of lymphocytes.Engagement of 2B4 on NK cell surfaces with specific antibodies or CD48 can trigger cell mediated cytotoxicity, interferon γ secretion, phosphoinositol turnover and NK cell invasiveness.
    • $814
    7-10 days
    Size
    QTY
  • B7-H2/ICOSLG Protein, Human, Recombinant (His & Avi)
    TMPK-00192
    B7-H2, also known as B7-related protein (B7RP1), ICOS Ligand, and CD275, is an approximately 60 kDa transmembrane glycoprotein in the B7 family of immune regulatory molecules. B7-H2 is a ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. B7-H2/ICOSLG Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 29.5 kDa and the accession number is O75144.
    • $255
    7-10 days
    Size
    QTY
  • 2B4/CD244 Protein, Human, Recombinant (hFc)
    TMPY-00656
    2B4/CD244 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 49 kDa and the accession number is Q9BZW8-2.
    • $600
    7-10 days
    Size
    QTY
  • CD83 Protein, Mouse, Recombinant (hFc)
    TMPY-02229
    CD83 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 39.2 kDa and the accession number is O88324.
    • $600
    7-10 days
    Size
    QTY
  • CD83 Protein, Cynomolgus, Rhesus, Recombinant (His)
    TMPY-04257
    CD83 Protein, Cynomolgus, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 15.4 kDa and the accession number is F6WX37.
    • $600
    7-10 days
    Size
    QTY
  • CD38 Protein, Human, Recombinant (His), PE conjugated
    TMPY-05573
    CD38 Protein, Human, Recombinant (His), PE conjugated is expressed in HEK293 mammalian cells with His tag. The accession number is NP_001766.2.
    • $597
    In Stock
    Size
    QTY
  • CD38 Protein, Human, Recombinant (His), FITC conjugated
    TMPY-05574
    CD38 Protein, Human, Recombinant (His), FITC conjugated is expressed in HEK293 mammalian cells with His tag. The accession number is NP_001766.2.
    • $930
    7-10 days
    Size
    QTY
  • 2B4/CD244 Protein, Human, Recombinant (His & Avi), Biotinylated
    TMPY-06294
    2B4/CD244 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 25.52 kDa and the accession number is Q9BZW8-2.
    • $462
    7-10 days
    Size
    QTY
  • 2B4/CD244 Protein, Human, Recombinant (hFc & Avi), Biotinylated
    TMPY-06280
    2B4/CD244 Protein, Human, Recombinant (hFc & Avi), Biotinylated is expressed in HEK293 mammalian cells with hFc and Avi tag. The predicted molecular weight is 50.80 kDa and the accession number is Q9BZW8-2.
    • $462
    7-10 days
    Size
    QTY
  • BTLA Protein, Human, Recombinant (His)
    TMPJ-00129
    B- and T-Lymphocyte Attenuator (BTLA) is a single-pass type I membrane protein containing 1 Ig-like V-type (immunoglobulin-like) domain. BTLA expression is induced during activation of T cells, and BTLA remains expressed on Th1 cells but not Th2 cells. Like PD1 and CTLA4, BTLA interacts with a B7 homolog, B7H4. However, unlike PD-1 and CTLA-4, BTLA displays T-Cell inhibition via interaction with tumor necrosis family receptors (TNF-R), not just the B7 family of cell surface receptors. BTLA is a lymphocyte inhibitory receptor that inhibits lymphocytes during immune response. BTLA also is a ligand for tumor necrosis factor (receptor) superfamily, member 14 (TNFRSF14), also known as herpes virus entry mediator (HVEM). BTLA-HVEM complexes negatively regulate T-cell immune responses.
    • $85
    7-10 days
    Size
    QTY
  • CD27 Ligand/CD70 Trimer Protein, Human, Recombinant (His)
    TMPK-00079
    CD70, also named CD27 ligand (CD27L), is a type II transmembrane glycoprotein belonging to the TNF superfamily (TNFSF) and has been designated TNFSF7.  CD70 is a cytokine that binds to CD27. Plays a role in T-cell activation. Induces the proliferation of costimulated T-cells and enhances the generation of cytolytic T-cells. CD27 Ligand/CD70 Trimer Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with N-His tag. The predicted molecular weight is 51.8 kDa and the accession number is P32970-1.
    • $487
    7-10 days
    Size
    QTY
  • BTLA Protein, Cynomolgus, Recombinant (His)
    TMPK-00530
    B- and T-lymphocyte attenuator (BTLA; CD272) is a 35 kDa type I transmembrane glycoprotein in the CD28 family of T cell costimulatory molecules. BTLA is a inhibitory receptor on lymphocytes that negatively regulates antigen receptor signaling via PTPN6/SHP-1 and PTPN11/SHP-2. BTLA may interact in cis (on the same cell) or in trans (on other cells) with TNFRSF14. BTLA Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 15.04 kDa and the accession number is A0A2K5W7M7.
    • $487
    7-10 days
    Size
    QTY
  • CD27 Ligand/CD70 Protein, Cynomolgus, Recombinant (His)
    TMPK-00666
    CD70, also named CD27 ligand (CD27L), is a type II transmembrane glycoprotein belonging to the TNF superfamily (TNFSF) and has been designated TNFSF7.  CD70 is a cytokine that binds to CD27. Plays a role in T-cell activation. Induces the proliferation of costimulated T-cells and enhances the generation of cytolytic T-cells. CD27 Ligand/CD70 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with N-His tag. The predicted molecular weight is 18.4 kDa and the accession number is G7PYU6-1.
    • $487
    7-10 days
    Size
    QTY
  • CD101 Protein, Mouse, Recombinant (His)
    TMPH-02722
    CD101 Protein, Mouse, Recombinant (His) is expressed in Baculovirus insect cells with N-10xHis tag. The predicted molecular weight is 29.6 kDa and the accession number is A8E0Y8.
    • $399
    20 days
    Size
    QTY
  • BTLA Protein, Human, Recombinant (hFc)
    TMPY-00175
    BTLA Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 38.8 kDa and the accession number is Q7Z6A9-2.
    • $600
    7-10 days
    Size
    QTY
  • BTLA Protein, Rat, Recombinant (mFc)
    TMPY-00461
    BTLA Protein, Rat, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 43.4 kDa and the accession number is Q6PNM1-1.
    • $600
    7-10 days
    Size
    QTY
  • RP105/CD180 Protein, Mouse, Recombinant (hFc)
    TMPY-01666
    RP105/CD180 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 95 kDa and the accession number is Q62192.
    • $600
    7-10 days
    Size
    QTY
  • RP105/CD180 Protein, Human, Recombinant (His)
    TMPY-01825
    RP105/CD180 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 69 kDa and the accession number is Q99467.
    • $320
    In Stock
    Size
    QTY
  • BTLA Protein, Rhesus, Recombinant (His)
    TMPY-05101
    BTLA Protein, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 19.3 kDa and the accession number is A0A8J8XCU2.
    • $398
    7-10 days
    Size
    QTY
  • BTLA Protein, Human, Recombinant (hFc & Avi), Biotinylated
    TMPY-05416
    BTLA Protein, Human, Recombinant (hFc & Avi), Biotinylated is expressed in HEK293 mammalian cells with hFc and Avi tag. The predicted molecular weight is 40.6 kDa and the accession number is Q7Z6A9-2.
    • $462
    7-10 days
    Size
    QTY
  • BTLA Protein, Human, Recombinant (isoform1, His)
    TMPY-06922
    BTLA Protein, Human, Recombinant (isoform1, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 15.19 kDa and the accession number is NM_181780.4.
    • $600
    7-10 days
    Size
    QTY