Powder: -20°C for 3 years | In solvent: -80°C for 1 year
EV-A71-IN-1 is a potent inhibitor of the human enterovirus A71 (EV-A71) capsid protein, with an EC50 of 0.27 μM against EV-A71. Acting as a capsid binder, EV-A71-IN-1 disrupts the crucial interaction between the viral VP1 protein and the host receptor hSCARB2. It displays broad-spectrum antiviral activity against various human enteroviruses, while being non-toxic to human cells (CC50 < 56.2 μM) [1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 6-8 weeks | $ 1,520.00 | |
50 mg | 6-8 weeks | $ 1,980.00 | |
100 mg | 6-8 weeks | $ 2,500.00 |
Description | EV-A71-IN-1 is a potent inhibitor of the human enterovirus A71 (EV-A71) capsid protein, with an EC50 of 0.27 μM against EV-A71. Acting as a capsid binder, EV-A71-IN-1 disrupts the crucial interaction between the viral VP1 protein and the host receptor hSCARB2. It displays broad-spectrum antiviral activity against various human enteroviruses, while being non-toxic to human cells (CC50 > 56.2 μM) [1]. |
In vitro | EV-A71-IN-1 (compound 12s) demonstrates efficacy across various EV-A71 strains (BrCr, GZ-CII, EV71/HeN09, and EV71/G082) and extends its antiviral activity to encompass other notable enteroviruses, including CV-A16, EV-D68, Echov-6, CV-B2, and CV-B6 [1]. |
Molecular Weight | 369.44 |
Formula | C21H15N5S |
CAS No. | 2413648-96-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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EV-A71-IN-1 2413648-96-9 inhibitor inhibit