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Milnacipran hydrochloride

Name: Milnacipran hydrochloride
Brand: TargetMol
SKU: T1189
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1189Cas No. 101152-94-7

Alias Savella, Milnacipran HCl, Dalcipran

Milnacipran hydrochloride (Savella) is a serotonin and norepinephrine reuptake inhibitor used to treat major depressive disorders. Milnacipran hydrochloride is an enantiomer of milnacipran, which is used to treat fibromyalgia. Milnacipran hydrochloride and milnacipran have been associated with a low rate of transient elevations in serum aminotransferase levels during treatment and with rare instances of clinically apparent acute liver injury with jaundice.

Milnacipran hydrochloride

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Purity: 99.92%

Catalog No. T1189Alias Savella, Milnacipran HCl, DalcipranCas No. 101152-94-7

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$31	In Stock	In Stock
25 mg	$56	In Stock	In Stock
50 mg	$81	In Stock	In Stock
100 mg	$147	In Stock	In Stock
200 mg	$218	In Stock	In Stock
500 mg	$368	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.92%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Milnacipran hydrochloride (Savella) is a serotonin and norepinephrine reuptake inhibitor used to treat major depressive disorders. Milnacipran hydrochloride is an enantiomer of milnacipran, which is used to treat fibromyalgia. Milnacipran hydrochloride and milnacipran have been associated with a low rate of transient elevations in serum aminotransferase levels during treatment and with rare instances of clinically apparent acute liver injury with jaundice.
Targets&IC50	NET:77 nM, SERT:420 nM
In vitro	In rat prefrontal cortex, Milnacipran (10 and 30 mg/kg, p.o.) was found to dose-dependently increase extracellular levels of NA and 5-HT. In antidepressant animal behavioral models, Milnacipran (30 and 60 mg/kg, p.o.) significantly reduced immobility time in the forced swim test in rats. Similarly, in animal models of anxiety, Milnacipran (30 and 60 mg/kg, p.o.) notably decreased immobility time in the conditioned fear stress test. In freely moving guinea pigs' hypothalamus, treatment with Milnacipran (10 mg/kg and 40 mg/kg) resulted in a 57% and 47% reduction in the NA metabolite MHPG respectively. Furthermore, Milnacipran (<40 mg/kg, i.p.) increased extracellular levels of NA and 5-HT in the hypothalamus of freely moving guinea pigs in a dose-dependent manner.
In vivo	Over 80% of Milnacipran is excreted in the urine primarily in its unchanged form and as glucuronide conjugates, with less than 10% metabolized through CYP3A4 enzyme-mediated N-deethylation. At high concentrations, Milnacipran can inhibit certain ligand-gated ion channel receptors, including 5-HT3A (IC50: 185 μM), NMDA (IC50: 58.4 μM), and nACh (IC50: 14.3 μM) receptors.
Synonyms	Savella, Milnacipran HCl, Dalcipran

Chemical Properties

Molecular Weight	282.81
Formula	C₁₅H₂₃ClN₂O
Cas No.	101152-94-7
Smiles	Cl.C1[C@@H]([C@@]1(C(=O)N(CC)CC)c1ccccc1)CN
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 28.3 mg/mL (100.07 mM), Sonication is recommended.

DMSO: 50 mg/mL (176.8 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (7.07 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.5359 mL	17.6797 mL	35.3594 mL	176.7971 mL
5 mM	0.7072 mL	3.5359 mL	7.0719 mL	35.3594 mL
10 mM	0.3536 mL	1.7680 mL	3.5359 mL	17.6797 mL
20 mM	0.1768 mL	0.8840 mL	1.7680 mL	8.8399 mL
50 mM	0.0707 mL	0.3536 mL	0.7072 mL	3.5359 mL
100 mM	0.0354 mL	0.1768 mL	0.3536 mL	1.7680 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc