Shopping Cart
Remove All
Your shopping cart is currently empty
NPSR1 antagonist-1
Catalog No. T213173 Copy Product Info
🥰Excellent
NPSR1 antagonist-1 is a potent and peripherally restricted antagonist of the neuropeptide S receptor 1 (NPSR1). It can inhibit the expression of IL-6, PTGS2, IL-20, and CXCL8, and it also reduces TNF-α cytokine levels. NPSR1 antagonist-1 is useful in inflammation-related research, such as peritonitis studies.
NPSR1 antagonist-1
Copy Product Info🥰Excellent
Catalog No. T213173
NPSR1 antagonist-1 is a potent and peripherally restricted antagonist of the neuropeptide S receptor 1 (NPSR1). It can inhibit the expression of IL-6, PTGS2, IL-20, and CXCL8, and it also reduces TNF-α cytokine levels. NPSR1 antagonist-1 is useful in inflammation-related research, such as peritonitis studies.
NPSR1 antagonist-1
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | Inquiry | Inquiry | |
| 50 mg | Inquiry | Inquiry | Inquiry |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
Add to Quotation
For research use only—not for human use. No sales to individuals. Use as intended only.
Resource Download
Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | NPSR1 antagonist-1 is a potent and peripherally restricted antagonist of the neuropeptide S receptor 1 (NPSR1). It can inhibit the expression of IL-6, PTGS2, IL-20, and CXCL8, and it also reduces TNF-α cytokine levels. NPSR1 antagonist-1 is useful in inflammation-related research, such as peritonitis studies. |
| In vitro | NPSR1 antagonist-1 (Compound 6) exhibits IC50 values of 0.35 nM for NPSR1-A and 0.15 nM for NPSR1-B. In HEK293T cells, the IC50 for its inhibition of Npsr1 is 2.1 nM. Additionally, NPSR1 antagonist-1 (0.001-10000 nM, 30 mins) reduces levels of IL6, CXCL8, IL20, and PTGS2 in fibroblasts expressing NPSR1-A. |
| In vivo | Prior to zymosan injection, NPSR1 antagonist-1 (Compound 6) administered intraperitoneally at 10 mg/kg promotes the resolution of inflammation in a zymosan-induced peritonitis mouse model. Additionally, an intraperitoneal dose of NPSR1 antagonist-1 at 40 mg/kg prior to zymosan injection reduces TNF-α levels in the peritoneum of the same model. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
Citations
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Preview
Related Tags: buy NPSR1 antagonist-1 | purchase NPSR1 antagonist-1 | NPSR1 antagonist-1 cost | order NPSR1 antagonist-1 | NPSR1 antagonist-1 in vivo | NPSR1 antagonist-1 in vitro
Generate Quote
Catalog No.: Cas No.:
Add
| Size | Quantity | Unit Price | Amount | Operation |
|---|
Generate Quote
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2026 TargetMol Chemicals Inc. All Rights Reserved.