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BW 245C

Name: BW 245C
Brand: TargetMol
SKU: T14842
Price: 199 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T14842Cas No. 72814-32-5

Alias BW245C

BW 245C is a selective prostaglandin-like DP receptor (DP1) agonist, a prostaglandin analogue with inhibitory effects on the aggregation response of collagen, which can be used to study diseases such as stroke.

BW 245C

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Catalog No. T14842Alias BW245CCas No. 72814-32-5

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$199	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:≥99%

Appearance:Solid

Color:White

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COA HPLC MS

Product Introduction

Bioactivity

Description	BW 245C is a selective prostaglandin-like DP receptor (DP1) agonist, a prostaglandin analogue with inhibitory effects on the aggregation response of collagen, which can be used to study diseases such as stroke.
In vitro	The prostaglandin DP receptor agonist BW 245C (0.01-1μM) inhibited TGF-β-induced collagen secretion and increased intracellular cAMP in lung fibroblasts [3]. The use of the DP receptor agonist BW 245C (0.1-3μmol/L) dose-dependently increased the transendothelial resistance of human umbilical vein endothelial cells and decreased FITC-dextran permeability. Moreover, it elevated intracellular cAMP levels and subsequent protein kinase A (PKA) activity [4].
In vivo	Injection of the DP1 agonist BW 245C (100 nM, 20 uL) did not significantly increase MBP-positive eosinophils in the esophageal epithelial cells of OVA-sensitized guinea pigs [2]. WT and DP1 (-/-) mice underwent middle cerebral artery occlusion, followed by a single intraperitoneal injection of vehicle or 0.02, 0.2, or 2.0 mg/kg BW 245C, and then immediate reperfusion. The results showed that BW 245C treatment significantly increased baseline CBF in WT mice but not in DP1 (-/-) mice [1].
Synonyms	BW245C

Chemical Properties

Molecular Weight	368.47
Formula	C₁₉H₃₂N₂O₅
Cas No.	72814-32-5
Smiles	C(C[C@@H](O)C1CCCCC1)N2[C@@H](CCCCCCC(O)=O)C(=O)NC2=O
Relative Density.	1.167 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 30 mg/mL (81.42 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7139 mL	13.5696 mL	27.1393 mL	135.6963 mL
5 mM	0.5428 mL	2.7139 mL	5.4279 mL	27.1393 mL
10 mM	0.2714 mL	1.3570 mL	2.7139 mL	13.5696 mL
20 mM	0.1357 mL	0.6785 mL	1.3570 mL	6.7848 mL
50 mM	0.0543 mL	0.2714 mL	0.5428 mL	2.7139 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc