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PKR-IN-C51 (Synonyms: PKR-inhibitor-C51, PKRINC51, PKR inhibitor C51, PKR IN C51)

Name: PKR-IN-C51
Brand: TargetMol
SKU: T24647
Price: 79 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T24647 Copy Product Info

Purity: 98.94%

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PKR-IN-C51 is a dose-dependent and ATP-competitive protein kinase R (PKR) inhibitor that inhibits intracellular PKR activation and autophosphorylation in mouse macrophages with an IC50=9 μM and Ki=3.4 μM.Interferon-induced double-stranded RNA-activated protein kinase (PKR) is a widely expressed Ser/Thr kinase.

PKR-IN-C51

Copy Product Info

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Catalog No. T24647

Synonyms PKR-inhibitor-C51, PKRINC51, PKR inhibitor C51, PKR IN C51

Cas No. 1314594-23-4

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Pack Size	Price	USA Stock	Global Stock
2 mg	$79	In Stock	In Stock
5 mg	$129	In Stock	In Stock
10 mg	$213	In Stock	In Stock
25 mg	$396	In Stock	In Stock
50 mg	$588	In Stock	In Stock
100 mg	$839	-	In Stock
1 mL x 10 mM (in DMSO)	$143	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:98.94%

Appearance:Solid

Color:Yellow

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	PKR-IN-C51 is a dose-dependent and ATP-competitive protein kinase R (PKR) inhibitor that inhibits intracellular PKR activation and autophosphorylation in mouse macrophages with an IC50=9 μM and Ki=3.4 μM.Interferon-induced double-stranded RNA-activated protein kinase (PKR) is a widely expressed Ser/Thr kinase.
Synonyms	PKR-inhibitor-C51, PKRINC51, PKR inhibitor C51, PKR IN C51

Chemical Properties

Molecular Weight	367.45
Formula	C₂₃H₂₁N₅
Cas No.	1314594-23-4
Smiles	N1=CC=C(N=C1NCCC2=CNC=3C=CC=CC32)C=4C=5C=CC=CC5NC4C
Relative Density.	1.317 g/cm3 (Predicted)

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (272.15 mM), Sonication and heating are recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (10.89 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7215 mL	13.6073 mL	27.2146 mL	136.0729 mL
5 mM	0.5443 mL	2.7215 mL	5.4429 mL	27.2146 mL
10 mM	0.2721 mL	1.3607 mL	2.7215 mL	13.6073 mL
20 mM	0.1361 mL	0.6804 mL	1.3607 mL	6.8036 mL
50 mM	0.0544 mL	0.2721 mL	0.5443 mL	2.7215 mL
100 mM	0.0272 mL	0.1361 mL	0.2721 mL	1.3607 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc