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PKR-IN-C51

🥰Excellent
Catalog No. T24647Cas No. 1314594-23-4
Alias PKR-inhibitor-C51, PKRINC51, PKR inhibitor C51, PKR IN C51

PKR-IN-C51 is a dose-dependent and ATP-competitive protein kinase R (PKR) inhibitor that inhibits intracellular PKR activation and autophosphorylation in mouse macrophages with an IC50=9 μM and Ki=3.4 μM.Interferon-induced double-stranded RNA-activated protein kinase (PKR) is a widely expressed Ser/Thr kinase.

PKR-IN-C51

PKR-IN-C51

🥰Excellent
Purity: 98.94%
Catalog No. T24647Alias PKR-inhibitor-C51, PKRINC51, PKR inhibitor C51, PKR IN C51Cas No. 1314594-23-4
PKR-IN-C51 is a dose-dependent and ATP-competitive protein kinase R (PKR) inhibitor that inhibits intracellular PKR activation and autophosphorylation in mouse macrophages with an IC50=9 μM and Ki=3.4 μM.Interferon-induced double-stranded RNA-activated protein kinase (PKR) is a widely expressed Ser/Thr kinase.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
2 mg$83In StockIn Stock
5 mg$137In StockIn Stock
10 mg$225In StockIn Stock
25 mg$396In StockIn Stock
50 mg$588In StockIn Stock
100 mg$839-In Stock
200 mg$1,160-In Stock
1 mL x 10 mM (in DMSO)$152In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Purity:98.94%
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Product Introduction

Bioactivity
Description
PKR-IN-C51 is a dose-dependent and ATP-competitive protein kinase R (PKR) inhibitor that inhibits intracellular PKR activation and autophosphorylation in mouse macrophages with an IC50=9 μM and Ki=3.4 μM.Interferon-induced double-stranded RNA-activated protein kinase (PKR) is a widely expressed Ser/Thr kinase.
SynonymsPKR-inhibitor-C51, PKRINC51, PKR inhibitor C51, PKR IN C51
Chemical Properties
Molecular Weight367.45
FormulaC23H21N5
Cas No.1314594-23-4
SmilesN1=CC=C(N=C1NCCC2=CNC=3C=CC=CC32)C=4C=5C=CC=CC5NC4C
Relative Density.1.317 g/cm3 (Predicted)
ColorYellow
AppearanceSolid
Storage & Solubility Information
Storagekeep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 100 mg/mL (272.15 mM), Sonication and heating are recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (10.89 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.7215 mL13.6073 mL27.2146 mL136.0729 mL
5 mM0.5443 mL2.7215 mL5.4429 mL27.2146 mL
10 mM0.2721 mL1.3607 mL2.7215 mL13.6073 mL
20 mM0.1361 mL0.6804 mL1.3607 mL6.8036 mL
50 mM0.0544 mL0.2721 mL0.5443 mL2.7215 mL
100 mM0.0272 mL0.1361 mL0.2721 mL1.3607 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
% DMSO
%
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

PKRINC-51PKR-IN-C-51PKR-IN-C51PKRINC 51
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