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Anti-CXCL4 Antibody (6I377)
😃Good
Catalog No. TMAY-01268
Alias SCYB4, platelet factor 4, PF-4, CXCL4
Anti-CXCL4 Antibody (6I377) is a Mouse antibody targeting CXCL4. Anti-CXCL4 Antibody (6I377) can be used in ELISA.
Anti-CXCL4 Antibody (6I377)
Anti-CXCL4 Antibody (6I377)
😃Good
Catalog No. TMAY-01268Alias SCYB4, platelet factor 4, PF-4, CXCL4
Anti-CXCL4 Antibody (6I377) is a Mouse antibody targeting CXCL4. Anti-CXCL4 Antibody (6I377) can be used in ELISA.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $199 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-CXCL4 Antibody (6I377) is a Mouse antibody targeting CXCL4. Anti-CXCL4 Antibody (6I377) can be used in ELISA. |
| Synonyms | SCYB4, platelet factor 4, PF-4, CXCL4 |
| Ig Type | Mouse IgG1 |
| Clone | 6I377 |
| Reactivity | Human |
| Specificity | Human CXCL4/PF4 |
| Application | |
| Recommended Dose | ELISA: 1:1000-1:2000 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CXCL4/PF4 (rh CXCL4/PF4; TMPY-00741; NP_002610.1; Glu32-Ser101). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Platelet factor 4 (PF4), also known as chemokine (C-X-C motif) ligand 4 (CXCL4), is a small cytokine belonging to the CXC chemokine family. CXCL4/PF4 is released from the alpha-granules of activated platelets and binds with high affinity to heparin. Its major physiologic role appears to be neutralization of heparin-like molecules on the endothelial surface of blood vessels, thereby inhibiting local antithrombin III activity and promoting coagulation. As a strong chemoattractant for neutrophils and fibroblasts, CXCL4/PF4 probably has a role in inflammation and wound repair. This protein is released during platelet aggregation. CXCL4/PF4 neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. CXCL4 is chemotactic for neutrophils and monocytes. It inhibits endothelial cell proliferation, the short form is a more potent inhibitor than the longer form. CXCL4/PF4 is up-regulated in human liver fibrosis and that it plays a nonredundant, functional role in experimental liver fibrosis by mediating stellate cell proliferation, migration, and intrahepatic immune cell recruitment. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein: Human CXCL4/PF4 Protein (TMPY-00741) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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