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Anti-CXCL4 Antibody (6I377)

😃Good
Catalog No. TMAY-01268
Alias SCYB4, platelet factor 4, PF-4, CXCL4

Anti-CXCL4 Antibody (6I377) is a Mouse antibody targeting CXCL4. Anti-CXCL4 Antibody (6I377) can be used in ELISA.

Anti-CXCL4 Antibody (6I377)

Anti-CXCL4 Antibody (6I377)

😃Good
Catalog No. TMAY-01268Alias SCYB4, platelet factor 4, PF-4, CXCL4
Anti-CXCL4 Antibody (6I377) is a Mouse antibody targeting CXCL4. Anti-CXCL4 Antibody (6I377) can be used in ELISA.
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100 μL$199 7-10 days
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Product Introduction

Bioactivity
Description
Antibody Type: Mouse Monoclonal

Application: ELISA

Reactivity: Human
AliasSCYB4, platelet factor 4, PF-4, CXCL4
Ig Type
Mouse IgG1
Clone
6I377
Reactivity
Human
Application
ELISA
Recommended Dose
ELISA: 1:1000-1:2000
Antibody Type
Monoclonal
Host SpeciesMouse
ConstructionThis antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CXCL4/PF4 (rh CXCL4/PF4; TMPY-00741; NP_002610.1; Glu32-Ser101). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
PurificationProtein A
AppearanceLiquid
Formulation0.2 μm filtered solution in PBS
Research BackgroundPlatelet factor 4 (PF4), also known as chemokine (C-X-C motif) ligand 4 (CXCL4), is a small cytokine belonging to the CXC chemokine family. CXCL4/PF4 is released from the alpha-granules of activated platelets and binds with high affinity to heparin. Its major physiologic role appears to be neutralization of heparin-like molecules on the endothelial surface of blood vessels, thereby inhibiting local antithrombin III activity and promoting coagulation. As a strong chemoattractant for neutrophils and fibroblasts, CXCL4/PF4 probably has a role in inflammation and wound repair. This protein is released during platelet aggregation. CXCL4/PF4 neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. CXCL4 is chemotactic for neutrophils and monocytes. It inhibits endothelial cell proliferation, the short form is a more potent inhibitor than the longer form. CXCL4/PF4 is up-regulated in human liver fibrosis and that it plays a nonredundant, functional role in experimental liver fibrosis by mediating stellate cell proliferation, migration, and intrahepatic immune cell recruitment.
Related Conjugates and Formulations
Conjucates
Unconjugated
Antigen Details
Immunogen
Recombinant Protein: Human CXCL4/PF4 Protein (TMPY-00741)
Antigen Species
Human
Chemical Properties
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
TransportShipping with blue ice.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

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