Shopping Cart

Your shopping cart is currently empty

Apyramide

Name: Apyramide
Brand: TargetMol
SKU: T10355
Price: 41 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

😃Good

Catalog No. T10355Cas No. 68483-33-0

Apyramide is an anti-inflammatory agent (NSAID) that acts as a prodrug of indomethacin, a potent, blood-brain permeable, and nonselective inhibitor of COX1 and COX2.

Apyramide

Copy Product Info

😃Good

Purity: 99.93%

Catalog No. T10355Cas No. 68483-33-0

Apyramide is an anti-inflammatory agent (NSAID) that acts as a prodrug of indomethacin, a potent, blood-brain permeable, and nonselective inhibitor of COX1 and COX2.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$41	In Stock	In Stock
10 mg	$72	In Stock	In Stock
25 mg	$125	In Stock	In Stock
50 mg	$183	In Stock	In Stock
100 mg	$248	In Stock	In Stock
200 mg	$340	-	In Stock
1 mL x 10 mM (in DMSO)	$58	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.93%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Apyramide is an anti-inflammatory agent (NSAID) that acts as a prodrug of indomethacin, a potent, blood-brain permeable, and nonselective inhibitor of COX1 and COX2.
In vivo	Apyramide demonstrates significantly lower toxicity in rats and mice compared to indomethacin when administered orally or via i.p. route. It shows anti-inflammatory effects on carrageenin-induced cotton pellet granuloma, paw edema, and adjuvant arthritis, as well as antipyretic and analgesic activities [1].

Chemical Properties

Molecular Weight	490.93
Formula	C₂₇H₂₃ClN₂O₅
Cas No.	68483-33-0
Smiles	C(=O)(N1C=2C(C(CC(OC3=CC=C(NC(C)=O)C=C3)=O)=C1C)=CC(OC)=CC2)C4=CC=C(Cl)C=C4
Relative Density.	1.29g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (112.03 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0370 mL	10.1848 mL	20.3695 mL	101.8475 mL
5 mM	0.4074 mL	2.0370 mL	4.0739 mL	20.3695 mL
10 mM	0.2037 mL	1.0185 mL	2.0370 mL	10.1848 mL
20 mM	0.1018 mL	0.5092 mL	1.0185 mL	5.0924 mL
50 mM	0.0407 mL	0.2037 mL	0.4074 mL	2.0370 mL
100 mM	0.0204 mL	0.1018 mL	0.2037 mL	1.0185 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc