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Timolol hemimaleate

Name: Timolol hemimaleate
Brand: TargetMol
SKU: T87530
Rating: 4.5 (1 reviews)

(Synonyms: MK 950 hemimaleate, (S)-L-714,465 hemimaleate) Copy Product Info

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Synonyms: MK 950 hemimaleate, (S)-L-714,465 hemimaleate

Catalog No. T87530 Copy Product Info

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Timolol hemimaleate ((S)-L-714,465; MK 950), a β-blocker, is formulated for both systemic and topical use. It is commonly applied topically to decrease intraocular pressure in cases of open-angle glaucoma and ocular hypertension. Additionally, it is utilized in research for the treatment of infantile hemangiomas, hypertension, myocardial infarction, migraine prophylaxis, and atrial fibrillation. Moreover, Timolol has been recognized for its cardioprotective effects [1] [2].

Cas No. 33305-95-2

Pack Size	Price	USA Stock	Global Stock
25 mg	Inquiry	7-10 days	7-10 days
50 mg	Inquiry	7-10 days	7-10 days
100 mg	Inquiry	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Product Introduction

Bioactivity

Description	Timolol hemimaleate ((S)-L-714,465; MK 950), a β-blocker, is formulated for both systemic and topical use. It is commonly applied topically to decrease intraocular pressure in cases of open-angle glaucoma and ocular hypertension. Additionally, it is utilized in research for the treatment of infantile hemangiomas, hypertension, myocardial infarction, migraine prophylaxis, and atrial fibrillation. Moreover, Timolol has been recognized for its cardioprotective effects [1] [2].
In vitro	Timolol hemimaleate significantly prevents increased lipid peroxidation in the hearts of diabetic rats, induces a balanced ratio between oxidative stress and antioxidant defense, and provides important cardioprotection against diabetes-induced ERS and associated apoptotic effects [3].
In vivo	Timolol hemimaleate exhibits cardioprotective effects in diabetic rats by inhibiting the ERS response [3]. Animal model: 3-month-old male Wistar rats [3]. Dosage: 5 mg/kg. Administration: 5 mg/kg daily for 12 weeks. Result: Demonstrated cardioprotective effects.
Synonyms	MK 950 hemimaleate, (S)-L-714,465 hemimaleate

Chemical Properties

Molecular Weight	374.45
Formula	C₁₃H₂₄N₄O₃S.1/2C₄H₄O₄
Cas No.	33305-95-2
Smiles	OC(/C=C\C(O)=O)=O.CC(C)(C)NC[C@H](O)COC1=NSN=C1N2CCOCC2.CC(C)(C)NC[C@H](O)COC3=NSN=C3N4CCOCC4

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Related Tags: Timolol hemimaleate chemical structure | Timolol hemimaleate in vivo | Timolol hemimaleate in vitro | Timolol hemimaleate formula | Timolol hemimaleate molecular weight