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STAT3-IN-1

Name: STAT3-IN-1
Brand: TargetMol
SKU: T13009
Price: 55 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T13009Cas No. 2059952-75-7

STAT3-IN-1 selective and orally active inhibitor of STAT3(in HT29 and MDA-MB 231 cells, with IC50 values of 1.82 μM and 2.14 μM , respectively), induces tumor apoptosis.

STAT3-IN-1

🥰Excellent

Purity: 95.89%

Catalog No. T13009Cas No. 2059952-75-7

STAT3-IN-1 selective and orally active inhibitor of STAT3(in HT29 and MDA-MB 231 cells, with IC50 values of 1.82 μM and 2.14 μM , respectively), induces tumor apoptosis.

Pack Size	Price	Availability
1 mg	$55	In Stock
2 mg	$81	In Stock
5 mg	$133	In Stock
10 mg	$203	In Stock
25 mg	$368	In Stock
50 mg	$551	In Stock
100 mg	$793	In Stock
500 mg	$1,630	In Stock
1 mL x 10 mM (in DMSO)	$139	In Stock

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Batch Information

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Purity:95.89%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	STAT3-IN-1 selective and orally active inhibitor of STAT3(in HT29 and MDA-MB 231 cells, with IC50 values of 1.82 μM and 2.14 μM , respectively), induces tumor apoptosis.
Targets&IC50	STAT3:1.82 μM (in HT29 cells), STAT3:2.14 μM (in MDA-MB 231 cells)
In vitro	STAT3-IN-1 induces tumor cells apoptosis in MDA-MB-231 cells

Chemical Properties

Molecular Weight	475.53
Formula	C₂₈H₂₉NO₆
Cas No.	2059952-75-7
Smiles	COc1cc(OC)cc(\C=C\c2ccc(NC(=O)\C=C\c3cc(OC)c(OC)c(OC)c3)cc2)c1
Relative Density.	1.205 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 125 mg/mL (262.86 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1029 mL	10.5146 mL	21.0292 mL	105.1458 mL
5 mM	0.4206 mL	2.1029 mL	4.2058 mL	21.0292 mL
10 mM	0.2103 mL	1.0515 mL	2.1029 mL	10.5146 mL
20 mM	0.1051 mL	0.5257 mL	1.0515 mL	5.2573 mL
50 mM	0.0421 mL	0.2103 mL	0.4206 mL	2.1029 mL
100 mM	0.0210 mL	0.1051 mL	0.2103 mL	1.0515 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc