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STAT3-IN-1

Name: STAT3-IN-1
Brand: TargetMol
SKU: T13009
Price: 55 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T13009Cas No. 2059952-75-7

STAT3-IN-1 selective and orally active inhibitor of STAT3(in HT29 and MDA-MB 231 cells, with IC50 values of 1.82 μM and 2.14 μM , respectively), induces tumor apoptosis.

STAT3-IN-1

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Purity: 98.13%

Catalog No. T13009Cas No. 2059952-75-7

STAT3-IN-1 selective and orally active inhibitor of STAT3(in HT29 and MDA-MB 231 cells, with IC50 values of 1.82 μM and 2.14 μM , respectively), induces tumor apoptosis.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$55	In Stock	In Stock
5 mg	$133	In Stock	In Stock
10 mg	$188	In Stock	In Stock
25 mg	$322	In Stock	In Stock
50 mg	$469	In Stock	In Stock
100 mg	$689	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$139	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.13%

Appearance:Solid

Color:White to Yellow

Resource Download

COA HPLC LCMS HNMR

Product Introduction

Bioactivity

Description	STAT3-IN-1 selective and orally active inhibitor of STAT3(in HT29 and MDA-MB 231 cells, with IC50 values of 1.82 μM and 2.14 μM , respectively), induces tumor apoptosis.
Targets&IC50	STAT3:1.82 μM (in HT29 cells), STAT3:2.14 μM (in MDA-MB 231 cells)
In vitro	STAT3-IN-1 induces tumor cells apoptosis in MDA-MB-231 cells

Chemical Properties

Molecular Weight	475.53
Formula	C₂₈H₂₉NO₆
Cas No.	2059952-75-7
Smiles	COc1cc(OC)cc(\C=C\c2ccc(NC(=O)\C=C\c3cc(OC)c(OC)c(OC)c3)cc2)c1
Relative Density.	1.205 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 125 mg/mL (262.86 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1029 mL	10.5146 mL	21.0292 mL	105.1458 mL
5 mM	0.4206 mL	2.1029 mL	4.2058 mL	21.0292 mL
10 mM	0.2103 mL	1.0515 mL	2.1029 mL	10.5146 mL
20 mM	0.1051 mL	0.5257 mL	1.0515 mL	5.2573 mL
50 mM	0.0421 mL	0.2103 mL	0.4206 mL	2.1029 mL
100 mM	0.0210 mL	0.1051 mL	0.2103 mL	1.0515 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc