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Lomitapide Mesylate

Name: Lomitapide Mesylate
Brand: TargetMol
SKU: T2545
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T2545Cas No. 202914-84-9

Alias BMS-201038 mesylate, AEGR-733 mesylate

Lomitapide Mesylate (BMS-201038 mesylate) is a methanesulfonic acid form of lomitapide, a small molecule inhibitor of microsomal triglyceride transfer protein.

Lomitapide Mesylate

🥰Excellent

Purity: 99.92%

Catalog No. T2545Alias BMS-201038 mesylate, AEGR-733 mesylateCas No. 202914-84-9

Lomitapide Mesylate (BMS-201038 mesylate) is a methanesulfonic acid form of lomitapide, a small molecule inhibitor of microsomal triglyceride transfer protein.

Pack Size	Price	Availability
1 mg	$30	In Stock
5 mg	$59	In Stock
10 mg	$97	In Stock
25 mg	$147	In Stock
50 mg	$238	In Stock
100 mg	$358	In Stock
200 mg	$528	In Stock
1 mL x 10 mM (in DMSO)	$88	In Stock

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Batch Information

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Purity:99.92%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	Lomitapide Mesylate (BMS-201038 mesylate) is a methanesulfonic acid form of lomitapide, a small molecule inhibitor of microsomal triglyceride transfer protein.
Targets&IC50	MTP:8 nM
Synonyms	BMS-201038 mesylate, AEGR-733 mesylate

Chemical Properties

Molecular Weight	789.83
Formula	C₄₀H₄₁F₆N₃O₅S
Cas No.	202914-84-9
Smiles	CS(O)(=O)=O.FC(F)(F)CNC(=O)C1(CCCCN2CCC(CC2)NC(=O)c2ccccc2-c2ccc(cc2)C(F)(F)F)c2ccccc2-c2ccccc12
Relative Density.	no data available
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: 93 mg/mL (117.75 mM), Sonication is recommended.

DMSO: 122 mg/mL (154.46 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (5.06 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	1.2661 mL	6.3305 mL	12.6610 mL	63.3048 mL
5 mM	0.2532 mL	1.2661 mL	2.5322 mL	12.6610 mL
10 mM	0.1266 mL	0.6330 mL	1.2661 mL	6.3305 mL
20 mM	0.0633 mL	0.3165 mL	0.6330 mL	3.1652 mL
50 mM	0.0253 mL	0.1266 mL	0.2532 mL	1.2661 mL
100 mM	0.0127 mL	0.0633 mL	0.1266 mL	0.6330 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc