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ATC 0175 free base

Name: ATC 0175 free base
Brand: TargetMol
SKU: T26677
Price: 99 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T26677Cas No. 509118-03-0

Alias ATC0175 free base

ATC0175 is a potent, selective, and orally active antagonist of the melanin-concentrating hormone 1 receptor (MCH1R), with IC50 values of 13.5 nM for MCH1R and greater than 10,000 nM for MCH2R, demonstrating antidepressant and anxiolytic effects in animal models and providing strong experimental relevance for depression and anxiety disorder research.

ATC 0175 free base

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Purity: 99.73%

Catalog No. T26677Alias ATC0175 free baseCas No. 509118-03-0

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$99	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.73%

Appearance:Solid

Color:White

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COA LCMS

Product Introduction

Bioactivity

Description	ATC0175 is a potent, selective, and orally active antagonist of the melanin-concentrating hormone 1 receptor (MCH1R), with IC50 values of 13.5 nM for MCH1R and greater than 10,000 nM for MCH2R, demonstrating antidepressant and anxiolytic effects in animal models and providing strong experimental relevance for depression and anxiety disorder research.
Targets&IC50	MCH2R:>10000 nM, MCH1R:13.5 nM
In vivo	Method: ATC0175 was administered orally at 1, 3, or 10 mg/kg in behavioral immobility tests. Result: ATC0175 significantly and dose-dependently reduced immobility time[1].
Synonyms	ATC0175 free base

Chemical Properties

Molecular Weight	425.47
Formula	C₂₃H₂₅F₂N₅O
Cas No.	509118-03-0
Smiles	N(C)(C)C=1C2=C(N=C(N[C@H]3CC[C@@H](NC(=O)C4=CC(F)=C(F)C=C4)CC3)N1)C=CC=C2
Relative Density.	1.30 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 10 mg/mL (23.5 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3503 mL	11.7517 mL	23.5034 mL	117.5171 mL
5 mM	0.4701 mL	2.3503 mL	4.7007 mL	23.5034 mL
10 mM	0.2350 mL	1.1752 mL	2.3503 mL	11.7517 mL
20 mM	0.1175 mL	0.5876 mL	1.1752 mL	5.8759 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc