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Cromolyn sodium

Name: Cromolyn sodium
Brand: TargetMol
SKU: T1260
Price: 48 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1260Cas No. 15826-37-6

Alias Sodium cromoglycate, FPL-670, FPL 670 (Cromolyn) Disodium, Disodium Cromoglycate

Cromolyn sodium (FPL-670) is a chromone complex that acts by inhibiting the release of chemical mediators from sensitized mast cells.

Cromolyn sodium

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Purity: 99.95%

Catalog No. T1260Alias Sodium cromoglycate, FPL-670, FPL 670 (Cromolyn) Disodium, Disodium CromoglycateCas No. 15826-37-6

Cromolyn sodium (FPL-670) is a chromone complex that acts by inhibiting the release of chemical mediators from sensitized mast cells.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 g	$48	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.95%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Cromolyn sodium AI Summary

Cromolyn sodium exhibits significant antiallergic activity, demonstrated in various models including the rat passive cutaneous anaphylaxis (PCA) test and histamine release inhibition assays. In PCA tests in rats, it shows inhibitory effects with ED50 values ranging from 0.3 mg/kg to 8.0 mg/kg, depending on the administration route (intravenous, intraperitoneal, or oral). The compound displays potent inhibition rates, such as up to 89% inhibition at 10 mg/kg intraperitoneally and 97% at 10 mg/kg intravenously. Additionally, it inhibits histamine release from rat mast cells with an IC50 of 3000.0 nM. These findings highlight Cromolyn sodium as a promising candidate for treating allergic reactions by effectively inhibiting histamine release and IgE-mediated anaphylactic responses..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Cromolyn sodium (FPL-670) is a chromone complex that acts by inhibiting the release of chemical mediators from sensitized mast cells.
Targets&IC50	GSK-3β:2 μM (IC50)
Synonyms	Sodium cromoglycate, FPL-670, FPL 670 (Cromolyn) Disodium, Disodium Cromoglycate

Chemical Properties

Molecular Weight	512.33
Formula	C₂₃H₁₄Na₂O₁₁
Cas No.	15826-37-6
Smiles	[Na+].c1(cccc2c1c(=O)cc(o2)C(=O)[O-])OCC(O)COc1cccc2c1c(=O)cc(o2)C(=O)[O-].[Na+]
Relative Density.	no data available

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 5.13 mg/mL (10.01 mM), Sonication is recommended.

H2O: 50 mg/mL (97.59 mM), Sonication is recommended.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	1.9519 mL	9.7593 mL	19.5187 mL	97.5933 mL
5 mM	0.3904 mL	1.9519 mL	3.9037 mL	19.5187 mL
10 mM	0.1952 mL	0.9759 mL	1.9519 mL	9.7593 mL

H2O

	1mg	5mg	10mg	50mg
20 mM	0.0976 mL	0.4880 mL	0.9759 mL	4.8797 mL
50 mM	0.0390 mL	0.1952 mL	0.3904 mL	1.9519 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc