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MNF
(Synonyms: 3'-Methoxy-4'-nitroflavone) Copy Product Info
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Synonyms: 3'-Methoxy-4'-nitroflavone
Catalog No. T71938 Copy Product Info
Purity: 98.55%
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MNF is a specific aryl hydrocarbon receptor (AhR) antagonist that effectively inhibits TCDD-induced AhR signaling pathway activation, attenuates TCDD-induced activation of downstream signaling molecules Akt and Erk1/2 and TGFα expression, and reverses the anti-apoptotic effect of TCDD. It is commonly used in research on AhR-related functions and signaling pathways.
Cas No. 145370-39-4
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 25 mg | $1,520 | - | In Stock | |
| 50 mg | $1,980 | - | In Stock | |
| 100 mg | $2,500 | 6-8 weeks | 6-8 weeks |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:98.55%
Appearance:Solid
Color:White
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Product Introduction
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Chemical Properties
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| Description | MNF is a specific aryl hydrocarbon receptor (AhR) antagonist that effectively inhibits TCDD-induced AhR signaling pathway activation, attenuates TCDD-induced activation of downstream signaling molecules Akt and Erk1/2 and TGFα expression, and reverses the anti-apoptotic effect of TCDD. It is commonly used in research on AhR-related functions and signaling pathways. |
| In vitro | MNF (0.1–1000 nM; 24 h) can inhibit TCDD-dependent DRE-driven luciferase activity in MCF-10A cells at concentrations as low as 10 nM [1]. MNF (0.1–1000 nM; 3 days) reverses the TCDD-dependent inhibition of apoptosis in MCF-10A cells, with significant effects observed at concentrations of 100 nM and 1000 nM [1]. MNF (0.1–1000 nM; 6 h) attenuates Akt phosphorylation levels in MCF-10A cells, with significant inhibition observed at 1 nM and complete inhibition achieved at 100 nM [1]. MNF (0.1–1000 nM; 6 h) reverses TCDD-mediated Erk1,2 phosphorylation in MCF-10A cells at concentrations of 10 nM and above; when acting alone, a concentration of 1 nM enhances basal Erk1,2 activation [1]. MNF (0.1–100 nM; 6 h) completely abolishes TCDD-dependent TGFα mRNA expression in MCF-10A cells at concentrations as low as 1 nM [1]. MNF (0.5–2.5 μM) potently inhibits the basal deethylation activity of ethoxyhalogenated compounds by recombinant human CYP1A1 [2]. MNF (0.05–2.5 μM; 1.5–20 h) dose-dependently inhibits 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced ethoxyhalogen deethylation activity in HaCaT cells in vitro [2]. MNF (0.05–2.5 μM; 1.5–48 h) initially inhibited and subsequently enhanced FICZ-dependent CYP1A1 mRNA expression and ethoxyhalogen deethylation activity in HaCaT cells, with a significant enhancing effect observed at prolonged incubation times [2]. MNF (0.05–2.5 μM; 0–40 h) induces aromatin receptor-dependent ethoxyquin deethylation activity in HaCaT cells; this effect is dependent on endogenous FICZ in the culture medium [2]. MNF (0.05 μM; 0–30 h) induces AR-dependent CYP1A1 mRNA expression in HaCaT cells, a process that requires FICZ present in commercial cell culture media [2]. MNF (50 nM; 48 h) induces ethoxyhalogen deethylation activity in HaCaT cells only in the presence of 0.1 pM FICZ [2]. |
| Synonyms | 3'-Methoxy-4'-nitroflavone |
| Molecular Weight | 297.26 |
| Formula | C16H11NO5 |
| Cas No. | 145370-39-4 |
| Smiles | O=C1C=C(C2=CC(OC)=C([N+]([O-])=O)C=C2)OC3=C1C=CC=C3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: MNF chemical structure | MNF in vitro | MNF formula | MNF molecular weight
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