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Nuclear Receptors

Nuclear receptors are a class of proteins responsible for sensing steroids, thyroid hormones, vitamins, and certain other molecules.Nuclear receptors are specific to animals and are not found in protists, algae, fungi, or plants. There are 47 nuclear receptors in humans.These intracellular receptors work with other proteins to regulate the expression of specific genes thereby controlling the development, homeostasis, and metabolism of the organism. A unique property of nuclear receptors that differentiates them from other classes of receptors is their direct control of genomic DNA. Hence these receptors are classified as transcription factors. The regulation of gene expression by nuclear receptors often occurs in the presence of a ligand. Ligand binding to a nuclear receptor results in a conformational change activating the receptor. The result is up-or down-regulation of gene expression. Nuclear receptors play key roles in both embryonic development and adult homeostasis.

  • ER alpha Protein, Human, Recombinant (His)
    TMPJ-00762
    Estrogen Receptor is a major ligand-activated transcription factor belonging to the nuclear hormone receptor superfamily. Estrogen Receptor is composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but they also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative splicing results in several transcript variants, which differ in their 5' UTRs and use different promoters.
    • $184
    7-10 days
    Size
    QTY
  • Androgen receptor Protein, Human, Recombinant (His & Myc & SUMO)
    TMPH-00932
    Androgen receptor Protein, Human, Recombinant (His & Myc & SUMO) is expressed in E. coli.
    • $198
    20 days
    Size
    QTY
  • NR1I2 Protein, Human, Recombinant (His & Myc & SUMO)
    TMPH-01793
    NR1I2 Protein, Human, Recombinant (His & Myc & SUMO) is expressed in E. coli expression system with N-10xHis-SUMO and C-Myc tag. The predicted molecular weight is 69.8 kDa and the accession number is O75469.
    • $198
    20 days
    Size
    QTY
  • RORA Protein, Human, Recombinant (His)
    TMPH-01791
    RORA Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 57.6 kDa and the accession number is P35398.
    • $284
    20 days
    Size
    QTY
  • PPAR alpha/PPARA Protein, Human, Recombinant (His)
    TMPY-06830
    PPAR alpha/PPARA Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 31.36 kDa and the accession number is Q07869.
    • $600
    7-10 days
    Size
    QTY
  • LXR-alpha Protein, Human, Recombinant (His & Myc)
    TMPH-01819
    LXR-alpha Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 53.1 kDa and the accession number is Q13133.
    • $198
    20 days
    Size
    QTY
  • RORC Protein, Human, Recombinant (His & SUMO)
    TMPH-01792
    RORC Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 74.2 kDa and the accession number is P51449.
    • $198
    20 days
    Size
    QTY
  • NR2F6 Protein, Human, Recombinant (His & Myc)
    TMPH-01794
    NR2F6 Protein, Human, Recombinant (His & Myc) is expressed in HEK293 mammalian cells with N-6xHis-Myc tag. The predicted molecular weight is 47.0 kDa and the accession number is P10588.
    • $465
    20 days
    Size
    QTY
  • THRA Protein, Human, Recombinant (His)
    TMPH-02203
    Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.; Does not bind thyroid hormone and functions as a weak dominant negative inhibitor of thyroid hormone action. THRA Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 58.9 kDa and the accession number is P10827.
    • $360
    20 days
    Size
    QTY
  • THRB Protein, Human, Recombinant (His)
    TMPY-06821
    Thyroid hormone receptor beta (THRB), also known as TRbeta and NR1A2, belongs to the nuclear hormone receptor family. Featuring an N-terminal transactivation domain, a central DNA-binding domain, and a hormone/ligand-binding domain, THRB isoform 1/2 expression localizes predominately to the liver and pituitary, respectively. THRB regulates the feedback of T3-dependent thyrotropin-stimulating hormone (TSH) transcription in the pituitary by binding to thyroid hormone (TH) response elements present on promoters of TH-responsive genes. Located on chromosome 3p24, THRB gene mutation has been linked to autosomal dominant resistance to TH (RTH), which is characterized by goiter and elevated levels of T3, T4, and TSH. THRB is a known pharmacological target for the treatment of non-alcoholic steatohepatitis (NASH). THRB may be a target for future cancer therapies since its knockdown enhanced the viability of endometrial cancer cells and activated the mTOR-4EBP1/eIF4G pathway.
    • $600
    7-10 days
    Size
    QTY
  • ER beta Protein, Human, Recombinant (E. coli, His)
    TMPH-01304
    Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1/ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner.; Lacks ligand binding ability and has no or only very low ERE binding activity resulting in the loss of ligand-dependent transactivation ability. ER beta Protein, Human, Recombinant (E. coli, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 39.8 kDa and the accession number is Q92731.
    • $198
    20 days
    Size
    QTY
  • NR4A2 Protein, Human, Recombinant (His)
    TMPH-01797
    Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons. NR4A2 Protein, Human, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 68.6 kDa and the accession number is P43354.
    • $341
    20 days
    Size
    QTY
  • Vitamin D Receptor/VDR Protein, Human, Recombinant (His)
    TMPY-02706
    Vitamin D Receptor/VDR Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 50 kDa and the accession number is P11473.
    • $498
    7-10 days
    Size
    QTY
  • PPAR gamma/PPARG Protein, Human, Recombinant (His & GST)
    TMPY-02575
    Peroxisome proliferator-activated receptor gamma (PPARG), a nuclear hormone receptor, plays a critical role in the lipid and glucose homeostasis, adipocyte differentiation, as well as intracellular insulin-signaling events. The peroxisome proliferator-activated receptor gamma (PPARgamma) regulates osteoblast and osteoclast differentiation, and is the molecular target of thiazolidinediones (TZDs), insulin sensitizers that enhance glucose utilization and adipocyte differentiation. Peroxisome proliferator-activated receptor gamma (PPARG) is a transcription factor involved in atherosclerosis and related diseases. Peroxisome proliferator-activated receptor gamma (PPARG) plays an important role in the pathogenesis and maintenance of essential hypertension (EH).The functional single nucleotide polymorphisms in peroxisome proliferator-activated receptor gamma (PPARG) gene were predicted to be correlated with the susceptibility of colorectal cancer (CRC).
    • $386
    In Stock
    Size
    QTY
  • ER beta Protein, Human, Recombinant (His)
    TMPH-01305
    Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1/ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner.; Lacks ligand binding ability and has no or only very low ERE binding activity resulting in the loss of ligand-dependent transactivation ability. ER beta Protein, Human, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 61.1 kDa and the accession number is Q92731.
    • $231
    20 days
    Size
    QTY
  • NR2F6 Protein, Human, Recombinant (His & SUMO)
    TMPH-01795
    NR2F6 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 59.0 kDa and the accession number is P10588.
    • $284
    20 days
    Size
    QTY
  • THRB Protein, Human, Recombinant (His & SUMO)
    TMPH-02204
    Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.
    • $198
    20 days
    Size
    QTY
  • PPAR gamma Protein, Mouse, Recombinant (His)
    TMPH-02827
    PPAR gamma Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 63.3 kDa and the accession number is P37238.
    • $284
    20 days
    Size
    QTY
  • Ppard Protein, Human, Recombinant (His)
    TMPH-03755
    Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand.
    • $284
    20 days
    Size
    QTY
  • PPAR gamma Protein, Xenopus laevis, Recombinant (His)
    TMPH-03711
    Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. May play a role in the regulation of circadian rhythm.
    • $360
    20 days
    Size
    QTY
  • Vitamin D Receptor/VDR Protein, Mouse, Recombinant (His)
    TMPY-02987
    Vitamin D Receptor/VDR Protein, Mouse, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 49.28 kDa and the accession number is P48281.
    • $700
    7-10 days
    Size
    QTY
  • NR4A1 Protein, Human, Recombinant (His & Myc)
    TMPH-01796
    Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3'. May inhibit NF-kappa-B transactivation of IL2. Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation. Plays a role in the vascular response to injury. NR4A1 Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 69.5 kDa and the accession number is P22736.
    • $284
    20 days
    Size
    QTY
  • PPAR alpha/PPARA Protein, Mouse, Recombinant (His)
    TMPY-06837
    PPAR alpha/PPARA Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 31.49 kDa and the accession number is P23204.
    • $600
    7-10 days
    Size
    QTY