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Anti-MLH1 Antibody (9P46)
(Synonyms: MutL, E. coli, homolog of, 1, MutL protein homolog 1, MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli), MutL homolog 1 colon cancer nonpolyposis type 2, MutL homolog 1 (E. coli), MutL homolog 1, MLH1_HUMAN, MLH1, MLH 1, MGC5172, HNPCC2, HNPCC 2, HNPCC, hMLH1, hMLH 1, FCC2, FCC 2, DNA mismatch repair protein Mlh1, COCA2, COCA 2) Copy Product Info
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Synonyms: MutL, E. coli, homolog of, 1, MutL protein homolog 1, MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli), MutL homolog 1 colon cancer nonpolyposis type 2, MutL homolog 1 (E. coli), MutL homolog 1, MLH1_HUMAN, MLH1, MLH 1, MGC5172, HNPCC2, HNPCC 2, HNPCC, hMLH1, hMLH 1, FCC2, FCC 2, DNA mismatch repair protein Mlh1, COCA2, COCA 2
Catalog No. TMAC-02607 Copy Product Info
🥰Excellent
Anti-MLH1 Antibody (9P46) is a Rabbit antibody targeting MLH1. Anti-MLH1 Antibody (9P46) can be used in FCM,ICC/IF,IHC,IP,WB.
Anti-MLH1 Antibody
(9P46)
(9P46)
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 μL | $296 | 7-10 days | 7-10 days | |
| 100 μL | $496 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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| Description | Anti-MLH1 Antibody (9P46) is a Rabbit antibody targeting MLH1. Anti-MLH1 Antibody (9P46) can be used in FCM,ICC/IF,IHC,IP,WB. |
| Synonyms | MutL, E. coli, homolog of, 1, MutL protein homolog 1, MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli), MutL homolog 1 colon cancer nonpolyposis type 2, MutL homolog 1 (E. coli), MutL homolog 1, MLH1_HUMAN, MLH1, MLH 1, MGC5172, HNPCC2, HNPCC 2, HNPCC, hMLH1, hMLH 1, FCC2, FCC 2, DNA mismatch repair protein Mlh1, COCA2, COCA 2 |
| Ig Type | IgG |
| Clone | 9P46 |
| Reactivity | Human,Mouse,Rat |
| Application | |
| Recommended Dose | WB: 1:1000; IHC: 1:50-100; ICC/IF: 1:50-200; FCM: 1:50-100 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | Recombinant Antibody |
| Purification | ProA affinity purified |
| Appearance | Liquid |
| Formulation | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| Research Background | DNA-mismatch repair (MMR) is an essential process in maintaining genetic stability. Lack of a functional DNA-mismatch repair pathway is a common characteristic of several different types of human cancers, either due to an MMR gene mutation or promoter methylation gene silencing. MLH1 is an integral part of the protein complex responsible for mismatch repair and is expressed in lymphocytes, heart, colon, breast, lung, spleen, testis, prostate, thyroid and gall bladder tissues, and is methylated in several ovarian tumors. Loss of MLH1 protein expression is associated with a mutated phenotype, microsatellite instability and a predisposition to cancer. In hereditary nonpolyposis colorectal cancer (HNPCC), an autosomal dominant inherited cancer syndrome that signifies a high risk of colorectal and various other types of cancer, the MLH1 gene exhibits a pathogenic mutation. Certain cancer cell lines, including leukemia CCRF-CEM, colon HCT 116 and KM12, and ovarian cancers SK-OV-3 and IGROV-1, show complete deficiency of MLH1, while MLH1 is expressed in 60% of melanomas, 70% of noninvasive squamous cell carcinomas and 30% of invasive squamous cell carcinomas. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein |
| Uniprot ID |
| Molecular Weight | Theoretical: 85 kDa. |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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