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Moguisteine

Name: Moguisteine
Brand: TargetMol
SKU: T1169
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1169Cas No. 119637-67-1

Alias BBR-2173

Moguisteine (BBR-2173) is a new-type peripheral non-narcotic antitussive drug.

Moguisteine

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Purity: 99.98%

Catalog No. T1169Alias BBR-2173Cas No. 119637-67-1

Moguisteine (BBR-2173) is a new-type peripheral non-narcotic antitussive drug.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
50 mg	$29	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.98%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Moguisteine (BBR-2173) is a new-type peripheral non-narcotic antitussive drug.
In vitro	Moguisteine is a novel peripheral nonnarcotic antitussive agent that has proved to be as active as codeine in several experimental models of induced cough in guinea-pigs and dogs. It acts neither through the opiate receptors nor on the cough centre, and its action is possibly mediated by the interaction with rapidly adapting irritant receptors along the tracheobronchial tree. In controlled clinical trials, moguisteine has been shown to be safe and to effectively reduce cough associated with such respiratory disorders as acute upper respiratory tract infection, chronic bronchitis, pulmonary fibrosis and malignancies.
Synonyms	BBR-2173

Chemical Properties

Molecular Weight	339.41
Formula	C₁₆H₂₁NO₅S
Cas No.	119637-67-1
Smiles	C(CC(OCC)=O)(=O)N1C(COC2=C(OC)C=CC=C2)SCC1
Relative Density.	1.225 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 63 mg/mL (185.62 mM), Sonication is recommended.

Ethanol: 63 mg/mL (185.62 mM), Sonication is recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.89 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO/Ethanol

	1mg	5mg	10mg	50mg
1 mM	2.9463 mL	14.7314 mL	29.4629 mL	147.3145 mL
5 mM	0.5893 mL	2.9463 mL	5.8926 mL	29.4629 mL
10 mM	0.2946 mL	1.4731 mL	2.9463 mL	14.7314 mL
20 mM	0.1473 mL	0.7366 mL	1.4731 mL	7.3657 mL
50 mM	0.0589 mL	0.2946 mL	0.5893 mL	2.9463 mL
100 mM	0.0295 mL	0.1473 mL	0.2946 mL	1.4731 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc