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Anti-THRB Polyclonal Antibody

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Catalog No. TMAB-13516

Anti-THRB Polyclonal Antibody is a Rabbit antibody targeting THRB. Anti-THRB Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF,FCM,ELISA.

Anti-THRB Polyclonal Antibody

Anti-THRB Polyclonal Antibody

😃Good
Catalog No. TMAB-13516
Anti-THRB Polyclonal Antibody is a Rabbit antibody targeting THRB. Anti-THRB Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF,FCM,ELISA.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
50 μL$2217-10 days7-10 days
100 μL$3727-10 days7-10 days
200 μL$5287-10 days7-10 days
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
Anti-THRB Polyclonal Antibody is a Rabbit antibody targeting THRB. Anti-THRB Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF,FCM,ELISA.
Ig Type
IgG
Reactivity
Human
Application
IHC-P
IHC-Fr
IF
FCM
ELISA
Recommended Dose
IHC-P: 1:200-800; IHC-Fr: 1:400-800; IF: 1:100-500; FCM: 1μg/Test; ELISA: 1:5000-10000
Antibody Type
Polyclonal
Host SpeciesRabbit
Subcellular LocalizationNucleus.
ConstructionPolyclonal Antibody
PurificationProtein A purified
AppearanceLiquid
Formulation0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Concentration1mg/ml
Research BackgroundThyroid hormone receptors (TRs) are ligand-dependent transcription factors that mediate the biological activities of thyroid hormone (T3). Thyroid hormone receptor b2 (TRb2) is a high affinity receptor for triiodothyronine which belongs to the nuclear hormone receptor family and the NR1 subfamily. It is composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal steroid-binding domain. Defects in the receptor result in generalized thyroid hormone resistance (GTHR). GTHR is transmitted as an autosomal dominant trait, but an autosomal recessive form also exists. The disease is characterized by goiter, abnormal mental functions, increased susceptibility to infections, abnormal growth and bone maturation, tachycardia and deafness. GTHR patients also have high levels of circulating thyroid hormones (T3-T4), with normal or slightly elevated thyroid stimulating hormone.
Antigen Details
Immunogen
Recombinant Protein: human THRB protein
Antigen Species
Human
Gene Name
THRB
Gene ID
7068
Protein Name
Thyroid hormone receptor beta
Uniprot ID
P10828
Function
Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.
Chemical Properties
Molecular WeightTheoretical: 53 kDa.
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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