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Anti-15-PGDH Antibody (4Z123)
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Catalog No. TMAY-01750
Alias hydroxyprostaglandin dehydrogenase 15-(NAD), AV026552, 15-PGDH
Anti-15-PGDH Antibody (4Z123) is a Rabbit antibody targeting 15-PGDH. Anti-15-PGDH Antibody (4Z123) can be used in FCM,ICC/IF.
Anti-15-PGDH Antibody (4Z123)
Anti-15-PGDH Antibody (4Z123)
😃Good
Catalog No. TMAY-01750Alias hydroxyprostaglandin dehydrogenase 15-(NAD), AV026552, 15-PGDH
Anti-15-PGDH Antibody (4Z123) is a Rabbit antibody targeting 15-PGDH. Anti-15-PGDH Antibody (4Z123) can be used in FCM,ICC/IF.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $269 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-15-PGDH Antibody (4Z123) is a Rabbit antibody targeting 15-PGDH. Anti-15-PGDH Antibody (4Z123) can be used in FCM,ICC/IF. |
| Alias | hydroxyprostaglandin dehydrogenase 15-(NAD), AV026552, 15-PGDH |
| Ig Type | Monoclonal Rabbit IgG |
| Clone | 4Z123 |
| Reactivity | Human |
| Verified Activity | 1. Immunofluorescence staining of Human HPGD in Hela cells. Cells were fixed with 4% PFA, permeabilzed with 1% Triton X-100 in PBS, blocked with 10% serum, and incubated with Rabbit anti-Human HPGD monoclonal antibody (1:60) at 37°C 1 hour. Then cells were stained with the Alexa Fluor® 488-conjugated Goat Anti-rabbit IgG secondary antibody (green) and counterstained with DAPI (blue). Positive staining was localized to cytoplasm. 2. Flow cytometric analysis of Human HPGD expression on Jurkat cells. The cells were treated according to manufacturer’s manual (BD Pharmingen™ Cat. No. 554714), stained with purified anti-Human HPGD, then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells. |
| Application | FCM,ICC/IF |
| Recommended Dose | ICC-IF: 1:20-1:100; FCM: 1:25-1:100 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Human HPGD / 15-PGDH (rh HPGD / 15-PGDH; TMPY-01264; NP_000851.2; Met1-Gln266). |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | 15-hydroxyprostaglandin dehydrogenase [NAD+], also known as Prostaglandin dehydrogenase 1, HPGD, and PGDH1, is a member of the short-chain dehydrogenases/reductases (SDR) family. Prostaglandins (PGs) play a key role in the onset of labor in many species and regulate uterine contractility and cervical dilatation. Therefore, the regulation of prostaglandin output by PG synthesizing and metabolizing enzymes in the human myometrium may determine uterine activity patterns in human labor both at preterm and at term. Prostaglandin dehydrogenase (PGDH) metabolizes prostaglandins (PGs) to render them inactive. HPGD is down-regulated by cortisol, dexamethasone, and betamethasone and down-regulated in colon cancer. It is up-regulated by TGFB1. HPGD contributes to the regulation of events that are under the control of prostaglandin levels. HPGD catalyzes the NAD-dependent dehydrogenation of lipoxin A4 to form 15-oxo-lipoxin A4. and inhibits in vivo proliferation of colon cancer cells. Defects in HPGD are the cause of primary hypertrophic osteoarthropathy autosomal recessive (PHOAR), cranio-osteoarthropathy (COA), and isolated congenital nail clubbing. |
| Conjucates | Unconjugated |
| Others Formats | FITC |
| Antibody Types Available | 2 |
| Immunogen | Recombinant Human HPGD / 15-PGDH protein (TMPY-01264) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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