Sulfinalol is a compound that acts as an orally active β-adrenoceptor antagonist and directly induces vasodilation [1].

Sulfinalol exhibits both direct vasodilator and antihypertensive effects. In a study involving mongrel dogs weighing between 8.7 to 21.2 kg, which were anesthetized using pentobarbital (30-35 mg/kg, i.v., with a subsequent continuous infusion of 4 mg/kg/h), intraarterial injection of Sulfinalol at dosages ranging from 0 to 100 μg demonstrated an increase in blood flow in the sympathetically denervated hindlimb. Additionally, when administered orally at a dosage of 2.5 mg/kg to male spontaneously hypertensive rats (SHR), Sulfinalol effectively reduced blood pressure, showcasing its potential in managing hypertension.