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BMS-983970

Name: BMS-983970
Brand: TargetMol
SKU: T14683
Rating: 4.5 (1 reviews)

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Catalog No. T14683Cas No. 1584713-87-0

BMS-983970 is an oral inhibitor of pan-Notch, and for the treatment of multiplecancers.

BMS-983970

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Catalog No. T14683Cas No. 1584713-87-0

BMS-983970 is an oral inhibitor of pan-Notch, and for the treatment of multiplecancers.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$198	8-10 weeks	8-10 weeks
5 mg	$347	8-10 weeks	8-10 weeks
25 mg	$1,520	8-10 weeks	8-10 weeks
50 mg	$1,980	8-10 weeks	8-10 weeks
100 mg	$1,990	8-10 weeks	8-10 weeks
1 mL x 10 mM (in DMSO)	$396	8-10 weeks	8-10 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	BMS-983970 is an oral inhibitor of pan-Notch, and for the treatment of multiplecancers.
In vivo	BMS-983970 exhibits anti-tumor effects in models of T-cell acute lymphoblastic leukemia (T-ALL) and solid tumor xenografts[1].

Chemical Properties

Molecular Weight	518.5
Formula	C₂₆H₂₆F₄N₄O₃
Cas No.	1584713-87-0
Smiles	NC(=O)[C@@H](CC1CC1)[C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2ccccc2)c2cccc(F)c2NC1=O
Relative Density.	1.45 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (96.43 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 2.5 mg/mL (4.82 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9286 mL	9.6432 mL	19.2864 mL	96.4320 mL
5 mM	0.3857 mL	1.9286 mL	3.8573 mL	19.2864 mL
10 mM	0.1929 mL	0.9643 mL	1.9286 mL	9.6432 mL
20 mM	0.0964 mL	0.4822 mL	0.9643 mL	4.8216 mL
50 mM	0.0386 mL	0.1929 mL	0.3857 mL	1.9286 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc