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BMS-983970

Name: BMS-983970
Brand: TargetMol
SKU: T14683
Rating: 4.5 (1 reviews)

😃Good

Catalog No. T14683Cas No. 1584713-87-0

BMS-983970 is an oral inhibitor of pan-Notch, and for the treatment of multiplecancers.

BMS-983970

😃Good

Catalog No. T14683Cas No. 1584713-87-0

BMS-983970 is an oral inhibitor of pan-Notch, and for the treatment of multiplecancers.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$198	8-10 weeks	8-10 weeks
5 mg	$347	8-10 weeks	8-10 weeks
25 mg	$1,520	8-10 weeks	8-10 weeks
50 mg	$1,980	8-10 weeks	8-10 weeks
100 mg	$1,990	8-10 weeks	8-10 weeks
1 mL x 10 mM (in DMSO)	$396	8-10 weeks	8-10 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	BMS-983970 is an oral inhibitor of pan-Notch, and for the treatment of multiplecancers.
In vivo	BMS-983970 exhibits anti-tumor effects in models of T-cell acute lymphoblastic leukemia (T-ALL) and solid tumor xenografts[1].

Chemical Properties

Molecular Weight	518.5
Formula	C₂₆H₂₆F₄N₄O₃
Cas No.	1584713-87-0
Relative Density.	1.45 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (96.43 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9286 mL	9.6432 mL	19.2864 mL	96.4320 mL
5 mM	0.3857 mL	1.9286 mL	3.8573 mL	19.2864 mL
10 mM	0.1929 mL	0.9643 mL	1.9286 mL	9.6432 mL
20 mM	0.0964 mL	0.4822 mL	0.9643 mL	4.8216 mL
50 mM	0.0386 mL	0.1929 mL	0.3857 mL	1.9286 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc