DCLK1 Protein, Human, Recombinant

Name: DCLK1 Protein, Human, Recombinant
Brand: TargetMol
SKU: TMPY-04752
Rating: 4.5 (1 reviews)

(Synonyms: doublecortin-like kinase 1, DCLK, DCDC3A, DCAMKL1, CLICK1, CL1) Copy Product Info

Synonyms: doublecortin-like kinase 1, DCLK, DCDC3A, DCAMKL1, CLICK1, CL1

Catalog No. TMPY-04752 Copy Product Info

DCLK1 Protein, Human, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 78.5 kDa and the accession number is O15075-1.

Pack Size	Price	USA Stock	Global Stock
10 µg	$152	7-10 days	7-10 days
20 µg	$248	7-10 days	7-10 days
50 µg	$577	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	The specific activity was determined to be > 3.5 nmol/min/mg using synthetic Autocamtide-2 peptide (KKALRRQETVDAL-amide) as substrate.
Description	DCLK1 Protein, Human, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 78.5 kDa and the accession number is O15075-1.
Species	Human
Expression System	Baculovirus Insect Cells
Tag	Tag Free
Accession Number	O15075-1
Construction	A DNA sequence encoding the human DCLK1 ( O15075-1) (Met 1-Val 705) was expressed and purified with two additional amino acids (Gly & Pro ) at the N-terminus. Predicted N terminal: Gly
Protein Purity	> 80 % as determined by SDS-PAGE
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Supplied as sterile 20 mM Tris, 500 mM NaCl, 10% glycerol, pH 7.4.
Reconstitution	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Synonyms	doublecortin-like kinase 1, DCLK, DCDC3A, DCAMKL1, CLICK1, CL1
Research Background	DCAMKL1, also known as DCLK1, is a member of the protein kinase superfamily and the doublecortin family. It contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. DCAMKL1 is involved in several different cellular processes, including neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis. Its microtubule-polymerizing activity is independent of its protein kinase activity. DCAMKL1 may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. It may also participate in functions of the mature nervous system.

Chemical Properties

Molecular Weight

78.5 kDa (predicted); 64 kDa (reducing condition, due to glycosylation)

Storage & Solubility Information

Shipping	Proteins are shipped with blue ice.
Storage	It is recommended to store the product under sterile conditions at -20°C to -80°C. Samples are stable for up to 12 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.