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JNJ-38158471

Name: JNJ-38158471
Brand: TargetMol
SKU: T22349
Price: 34 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T22349Cas No. 951151-97-6

Alias CS-2660

JNJ-38158471 (CS-2660), a highly selective, orally available, well tolerated VEGFR2 inhibitor with IC50 of 40 nM, inhibits closely related tyrosine kinases such as Ret and Kit with IC50 of 180 nM and 500 nM.

JNJ-38158471

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Purity: 97.08%

Catalog No. T22349Alias CS-2660Cas No. 951151-97-6

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$34	In Stock	In Stock
5 mg	$75	In Stock	In Stock
10 mg	$111	In Stock	In Stock
25 mg	$191	In Stock	In Stock
50 mg	$278	In Stock	In Stock
100 mg	$375	-	In Stock
200 mg	$515	-	In Stock
1 mL x 10 mM (in DMSO)	$81	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:97.08%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

JNJ-38158471 AI Summary

JNJ-38158471 shows bioactivity as an inhibitor of various kinases, including CSF1R, VEGFR2, FLT1, FLT3, FLT4, KIT, PDGFRalpha, and RET, with varying IC50 values. It exhibits significant antitumor activity in A431, HCT116, and A375 human cancer cell xenografted mouse models. The pharmacokinetic profile demonstrates good oral bioavailability, moderate half-life, and clearance rates in BALB/c mice and rats..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	JNJ-38158471 (CS-2660), a highly selective, orally available, well tolerated VEGFR2 inhibitor with IC50 of 40 nM, inhibits closely related tyrosine kinases such as Ret and Kit with IC50 of 180 nM and 500 nM.
Targets&IC50	c-Kit:500 nM, RET:180 nM, VEGFR2:40 nM
Synonyms	CS-2660

Chemical Properties

Molecular Weight	364.79
Formula	C₁₅H₁₇ClN₆O₃
Cas No.	951151-97-6
Smiles	CCNC(=O)Nc1ccc(Oc2ncnc(N)c2\C=N\OC)cc1Cl
Relative Density.	1.42±0.1 g/cm3 (20 °C, 760 mmHg)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 30 mg/mL (82.24 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 2 mg/mL (5.48 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7413 mL	13.7065 mL	27.4130 mL	137.0652 mL
5 mM	0.5483 mL	2.7413 mL	5.4826 mL	27.4130 mL
10 mM	0.2741 mL	1.3707 mL	2.7413 mL	13.7065 mL
20 mM	0.1371 mL	0.6853 mL	1.3707 mL	6.8533 mL
50 mM	0.0548 mL	0.2741 mL	0.5483 mL	2.7413 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc