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IL-17A Protein, Human, Recombinant (Avi & His), Biotinylated
(Synonyms: ILA17, IL-17A, IL-17, IL17, CTLA-8, CTLA8) Copy Product InfoSynonyms: ILA17, IL-17A, IL-17, IL17, CTLA-8, CTLA8
Catalog No. TMPY-07090 Copy Product Info
IL-17A Protein, Human, Recombinant (Avi & His), Biotinylated is expressed in HEK293 Cells. The accession number is Q16552.
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| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 5 µg | $167 | 7-10 days | 7-10 days | |
| 10 µg | $277 | 7-10 days | 7-10 days | |
| 20 µg | $462 | 7-10 days | 7-10 days | |
| 50 µg | $743 | 7-10 days | 7-10 days | |
| 100 µg | $1,220 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Bioactivity | Immobilized IL-17RA Protein, Human, Recombinant (hFc) (Cat#TMPY-05430) at 2 μg/mL (100 μL/well) can bind IL-17A Protein, Human, Recombinant (Avi & His), Biotinylated (Cat#TMPY-07090) , the EC50 is 4-12 ng/mL. |
| Description | IL-17A Protein, Human, Recombinant (Avi & His), Biotinylated is expressed in HEK293 Cells. The accession number is Q16552. |
| Species | Human |
| Expression System | HEK293 Cells |
| Tag | N-Avi-His |
| Accession Number | Q16552 |
| Construction | A DNA sequence encoding the Human IL17A (Q16552) (Gly24-Ala155) was expressed with a N-terminal polyhistidine tagged AVI tag at the C-terminus. The expressed protein was biotinylated in vivo by the Biotin-Protein ligase (BirA enzyme) which is co-expressed. |
| Protein Purity | ≥ 95% as determined by SDS-PAGE. ≥ 95% as determined by SEC-HPLC. ≥ 95% as determined by SEC-MALS(Routinely tested). |
| Endotoxin | < 1.0 EU/μg of the protein as determined by the LAL method. |
| Formulation | Lyophilized from sterile PBS, pH 7.4. Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
| Reconstitution | Please refer to the lot-specific COA. |
| Synonyms | ILA17, IL-17A, IL-17, IL17, CTLA-8, CTLA8 |
| Research Background | IL17, also known as IL17a, is a cytokine that belongs to the IL-17 family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation, and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the innate (monocytes, macrophages, dendritic cells) and adaptive (T- and B-cells) immune systems. The IL-17 family of cytokines includes six members, IL-17/IL-17A, IL-17B, IL-17C, IL-17D, IL-17E/IL-25, and IL-17F, which are produced by multiple cell types. IL-17 regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of IL-17 are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis, and multiple sclerosis.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
| Molecular Weight | 18.31 kDa (predicted); 41.6 kDa、24.6 kDa、22.5 kDa、21.1 kDa、19.4 kDa and 17.4 kDa (reducing contition, due to glycosylation); 43.6 kDa (SEC-MALS) |
| Shipping | In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice. |
| Storage | It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
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Related Tags: IL-17A Protein, Human, Recombinant (Avi & His), Biotinylated chemical structure | IL-17A Protein, Human, Recombinant (Avi & His), Biotinylated molecular weight
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