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MCaE12A, a potent modulator of RyR2, enhances the channel's sensitivity to cytoplasmic calcium concentrations, facilitating its opening. This compound serves as a critical instrument for examining RyR2 structure-to-function relationships and for modulating Ca2+ homeostasis and dynamics in cardiac cells [1].
Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | Inquiry | Backorder | |
50 mg | Inquiry | Backorder |
Description | MCaE12A, a potent modulator of RyR2, enhances the channel's sensitivity to cytoplasmic calcium concentrations, facilitating its opening. This compound serves as a critical instrument for examining RyR2 structure-to-function relationships and for modulating Ca2+ homeostasis and dynamics in cardiac cells [1]. |
Sequence | Gly-Asp-Cys-Leu-Pro-His-Leu-Lys-Leu-Cys-Lys-Ala-Asn-Lys-Asp-Cys-Cys-Ser-Lys-Lys-Cys-Lys-Arg-Arg-Gly-Thr-Asn-Ile-Glu-Lys-Arg-Cys-Arg (Disulfide bridge:Cys3-Cys17;Cys10-Cys21;Cys16-Cys32) |
Sequence Short | GDCLPHLKLCKANKDCCSKKCKRRGTNIEKRCR (Disulfide bridge:Cys3-Cys17;Cys10-Cys21;Cys16-Cys32) |
Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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