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Anti-Serotonin transporter Polyclonal Antibody
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Catalog No. TMAB-01678
Alias Solute carrier family 6 member 4, Sodium dependent serotonin transporter, SLC6A4, SERT1, SERT, SC6A4, OCD1, Na+/Cl-dependent serotonin transporter, HTT, hSERT, 5-hydroxytryptamine transporter, 5-HTTLPR, 5-HTT, 5HTT, 5HT transporter
Anti-Serotonin transporter Polyclonal Antibody is a Rabbit antibody targeting Serotonin transporter. Anti-Serotonin transporter Polyclonal Antibody can be used in IF,IHC-Fr,IHC-P,WB.
Anti-Serotonin transporter Polyclonal Antibody
Anti-Serotonin transporter Polyclonal Antibody
😃Good
Catalog No. TMAB-01678Alias Solute carrier family 6 member 4, Sodium dependent serotonin transporter, SLC6A4, SERT1, SERT, SC6A4, OCD1, Na+/Cl-dependent serotonin transporter, HTT, hSERT, 5-hydroxytryptamine transporter, 5-HTTLPR, 5-HTT, 5HTT, 5HT transporter
Anti-Serotonin transporter Polyclonal Antibody is a Rabbit antibody targeting Serotonin transporter. Anti-Serotonin transporter Polyclonal Antibody can be used in IF,IHC-Fr,IHC-P,WB.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $222 | 7-10 days | 7-10 days | |
| 100 μL | $373 | 7-10 days | 7-10 days | |
| 200 μL | $527 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-Serotonin transporter Polyclonal Antibody is a Rabbit antibody targeting Serotonin transporter. Anti-Serotonin transporter Polyclonal Antibody can be used in IF,IHC-Fr,IHC-P,WB. |
| Synonyms | Solute carrier family 6 member 4, Sodium dependent serotonin transporter, SLC6A4, SERT1, SERT, SC6A4, OCD1, Na+/Cl-dependent serotonin transporter, HTT, hSERT, 5-hydroxytryptamine transporter, 5-HTTLPR, 5-HTT, 5HTT, 5HT transporter |
| Ig Type | IgG |
| Reactivity | Human,Mouse,Rat (predicted:Chicken,Dog,Pig,Cow,Sheep,GuineaPig) |
| Verified Activity | 1. Sample: Cerebrum (Mouse) Lysate at 40 μg Primary: Anti-SLC6A4 (TMAB-01678) at 1/500 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 70 kDa Observed band size: 70 kDa 2. Paraformaldehyde-fixed, paraffin embedded (Rat brain); Antigen retrieval by microwave in sodium citrate buffer (pH6.0); Block endogenous peroxidase by 3% hydrogen peroxide for 30 minutes; Blocking buffer (3% BSA) at RT for 30 min; Antibody incubation with (Serotonin transporter) Polyclonal Antibody, Unconjugated (TMAB-01678) at 1:400 overnight at 4°C, followed by conjugation to the secondary antibody (labeled with HRP) and DAB staining. 3. Paraformaldehyde-fixed, paraffin embedded (Mouse brain); Antigen retrieval by microwave in sodium citrate buffer (pH6.0); Block endogenous peroxidase by 3% hydrogen peroxide for 30 minutes; Blocking buffer (3% BSA) at RT for 30 min; Antibody incubation with (Serotonin transporter) Polyclonal Antibody, Unconjugated (TMAB-01678) at 1:400 overnight at 4°C, followed by conjugation to the secondary antibody (labeled with HRP) and DAB staining.    |
| Application | |
| Recommended Dose | WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Cell membrane; Multi-pass membrane protein. Endomembrane system; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein. |
| Tissue Specificity | Expressed in platelets (at protein level). |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1 mg/mL |
| Research Background | This gene encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients, and depression-susceptibility in people experiencing emotional trauma. [provided by RefSeq, Jul 2008]. |
| Immunogen | KLH conjugated synthetic peptide: human 5-HTT |
| Antigen Species | Human |
| Gene Name | SLC6A4 |
| Gene ID | |
| Protein Name | Sodium-dependent serotonin transporter |
| Uniprot ID | |
| Biology Area | Drug metabolism,Sodium Channels,Serotonin / 5HT,Transporters,Drug metabolism |
| Function | Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner. |
| Molecular Weight | Theoretical: 70 kDa. |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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